Synthesis of smart graphene quantum dots: A benign biomaterial for prominent intracellular imaging and improvement of drug efficacy

Mondal, Maloy Kr.; Mukherjee, Suprabhat; Joardar, Nikhilesh; Roy, Debiprasad; Chowdhury, Pranesh; Babu, Santi P. Sinha

doi:10.1016/j.apsusc.2019.143562

Cited by 28 publications

(15 citation statements)

References 32 publications

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“…Similar with graphene, GQDs have capability to bind with a variety of aromatic bimolecular through the π–π stacking interaction and/or electrostatic binding. However compared with graphene sheets, GQDs exhibit improved biocompatibility and minimal toxicity [ 16 – 18 ], making them more promising materials for delivering of biologically active cargoes into living systems. In recent years, many researchers have been dedicated to the application of GQDs in drug delivery systems [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Introductionmentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…It is distributed across the early endosomes, Golgi apparatus and endoplasmic reticulum based on the cellular internalization and types of cells to enhance the specificity of drug delivery and therapeutic development (Cartiera et al 2009). In a recent report by Mondal et al (2019), luminous benign QDs have been reported for excellent intracellular imaging and delivery of antimicrobial drug (streptomycin). These streptomycin-loaded QDs were found to cure peritonitis in mice model, and the efficacy was higher than free streptomycin (Mondal et al 2019).…”

Section: Intracellular and Intercellular Targeted Delivery Of Nanoparmentioning

confidence: 99%

“…In a recent report by Mondal et al (2019), luminous benign QDs have been reported for excellent intracellular imaging and delivery of antimicrobial drug (streptomycin). These streptomycin-loaded QDs were found to cure peritonitis in mice model, and the efficacy was higher than free streptomycin (Mondal et al 2019). The various types of nanoparticles associated with the targeted delivery across the intracellular and intercellular components of cells are listed in Table 7.4.…”

Section: Intracellular and Intercellular Targeted Delivery Of Nanoparmentioning

confidence: 99%

Surface-Modified Noble Metal Nanoparticles as Antimicrobial Agents: Biochemical, Molecular and Therapeutic Perspectives

Das

Roy

Patra

et al. 2021

Nanotechnology for Advances in Medical Microbiology

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Despite the progress of the development of antimicrobial therapeutics, the whole world is still under pressure of several microbial diseases. Antimicrobial drug development is therefore considered as one of the most practicable research works at present time. Even most of the pharmaceutical companies are investing to develop better therapeutic solutions against the life-threatening infectious diseases caused by Mycobacterium tuberculosis, Helicobacter pylori, Vibrio cholerae, Entamoeba histolytica, Plasmodium falciparum and many others. These microbial pathogens are not only a curse for human health but also a result in huge economic losses by affecting the health of economically important animals like poultry, cattle and other livestock. Considering the urgency, several effective antibiotics have been developed to combat microbial diseases and are available in the market. However, emergence of resistance against these drugs due to the maluses has created an alarming situation. In this scenario, the use of bioactive noble metal nanoparticles (silver, gold and platinum nanoparticles) has shown better therapeutic efficiency in terms of low treatment dose, less toxicity and absence of microbial resistance. Moreover, the use of several surface modifiers, coating and stabilizing agents resulted in enhancement of the bioactivity, rapid delivery and controlled drug release, improvement of biocompatibility and cytotoxicity. In this chapter, we have presented a comprehensive overview on the antimicrobial efficacy of noble metal nanoparticles along with the mechanistic insights behind their activity at the cellular and molecular level. Nabarun Chandra Das, Bishnupada Roy, and Ritwik Patra have been contributed equally to this chapter.

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“…This smallness of the quantum dots gives them the unique optical properties like absorption and emission, thus resulting in better outshine than regular fluorescent compound and it is undeniable that GQDs become prominent due to their non-toxicity property, separating them from the other semiconductor QDs. Accordingly, this makes it easier and more reasonable to utilize GQDs in biological applications [ 79 , 80 ].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of heteroatoms in GQD strengthens several prospects to promote the PL as well. The proposed N,S-GQD system was enriched by hydrophilic functional groups like -COOH, -OH, and -NH 2 to provide solubility and drug conjugation [ 79 ]. In large scale productions of GQDs, their functionalization by sulfonation could provide re-dispersion in water and consistent fluorescence, and these sulfonated GQDs can be beneficial for intracellular Golgi imaging [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dots as Flourishing Nanomaterials for Bio-Imaging, Therapy Development, and Micro-Supercapacitors

et al. 2020

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Graphene quantum dots (GQDs) are considerably a new member of the carbon family and shine amongst other members, thanks to their superior electrochemical, optical, and structural properties as well as biocompatibility features that enable us to engage them in various bioengineering purposes. Especially, the quantum confinement and edge effects are giving GQDs their tremendous character, while their heteroatom doping attributes enable us to specifically and meritoriously tune their prospective characteristics for innumerable operations. Considering the substantial role offered by GQDs in the area of biomedicine and nanoscience, through this review paper, we primarily focus on their applications in bio-imaging, micro-supercapacitors, as well as in therapy development. The size-dependent aspects, functionalization, and particular utilization of the GQDs are discussed in detail with respect to their distinct nano-bio-technological applications.

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Synthesis of smart graphene quantum dots: A benign biomaterial for prominent intracellular imaging and improvement of drug efficacy

Cited by 28 publications

References 32 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Surface-Modified Noble Metal Nanoparticles as Antimicrobial Agents: Biochemical, Molecular and Therapeutic Perspectives

Graphene Quantum Dots as Flourishing Nanomaterials for Bio-Imaging, Therapy Development, and Micro-Supercapacitors

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