Carbohydrate polymer inspired silver nanoparticles for filaricidal and mosquitocidal activities: A comprehensive view

Saha, Swadhin K.; Roy, Priya; Saini, Prasanta; Mondal, Maloy Kr.; Chowdhury, Pranesh; Babu, Santi P. Sinha

doi:10.1016/j.carbpol.2015.11.007

Cited by 23 publications

(16 citation statements)

References 55 publications

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“…is the most active with respect to LC 50 values and cytotoxicity. The present system exhibited the lowest lethal doze and the highest non-toxicity [8,11,20]. The salient feature further justified the concept that chitosan and gold reinforced each other towards antifilarial activity.…”

Section: Comparative Antifilarial Activity and Cytotoxicitysupporting

confidence: 54%

“…But there are very few reports on antifilarial activity of metal nanoparticles. Most of the works done so far are concerned on the efficacy of silver nanoparticles against mosquito larvae and the vector of malaria and filaria [7,8]. Therefore, urgent development of therapeutics against filarial parasite is considered as the foremost agenda to the scientific community but at the same time cytotoxicity of the material should also be taken into consideration.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Chowdhury

Roy

Mukherjee

et al. 2018

Adv Compos Hybrid Mater

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Ultra-high stable chitosan functionalized gold nanoparticles (GNPs) of desired biopolymeric corona are synthesized without adding conventional hazardous reducing agents. The inherent unique set of properties like reducing ability, stabilizing effect, and mucoadhesiveness of chitosan is exhibited in the present work. Morphologies and ultra-stability of the synthesized materials are characterized by standard techniques. The mucoadhesiveness of the synthesized materials are well documented through the biological potency of the synthesized GNPs. The prominent bioactivity is evident from the antifilarial activity. The cellular and molecular level studies on the induction of oxidative stress, DNA damage, and undesirable protein expression clearly explain the antifilarial activities. Interestingly, the developed nanoparticle shows no detectable sign of toxicity when evaluated in vitro (rat peritoneal MФ) or in vivo (Wistar rat). Therefore, the synthesized green GNPs appear to be a substantial promise as an efficacious broad-spectrum nanotherapeutic agent with safe outcome for clinical attempt.

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Section: Comparative Antifilarial Activity and Cytotoxicitysupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Chowdhury

Roy

Mukherjee

et al. 2018

Adv Compos Hybrid Mater

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“…According to recent studies, AgNPs may become a candidate as a novel insecticide. Saha et al 195 confirmed that AgNPs were effective in killing filaria and larvae. AgNPs induced the cell apoptosis and destroyed parasites mainly through the generation of ROS.…”

Section: Medical Applications Of Agnpsmentioning

confidence: 97%

Silver nanoparticles: Synthesis, medical applications and biosafety

et al. 2020

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Silver nanoparticles (AgNPs) have been one of the most attractive nanomaterials in biomedicine due to their unique physicochemical properties. In this paper, we review the state-of-the-art advances of AgNPs in the synthesis methods, medical applications and biosafety of AgNPs. The synthesis methods of AgNPs include physical, chemical and biological routes. AgNPs are mainly used for antimicrobial and anticancer therapy, and also applied in the promotion of wound repair and bone healing, or as the vaccine adjuvant, anti-diabetic agent and biosensors. This review also summarizes the biological action mechanisms of AgNPs, which mainly involve the release of silver ions (Ag + ), generation of reactive oxygen species (ROS), destruction of membrane structure. Despite these therapeutic benefits, their biological safety problems such as potential toxicity on cells, tissue, and organs should be paid enough attention. Besides, we briefly introduce a new type of Ag particles smaller than AgNPs, silver Ångstrom (Å, 1 Å = 0.1 nm) particles (AgÅPs), which exhibit better biological activity and lower toxicity compared with AgNPs. Finally, we conclude the current challenges and point out the future development direction of AgNPs.

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“…In brief, the control and the treated parasites were incubated in 0.0004 mol/L H 2 DCFDA for 15 min in the dark. The parasites were washed in PBS and lysed using cell lysis buffer (Cell Lytic) and the absorbance of the supernatants was measured using a spectrofluorimeter (LS55, Perkin Elmer) [23, 24] with an excitation wavelength of 504 nm and an emission wavelength of 529 nm. Each experiment was performed in triplicate and repeated five times.…”

Section: Methodsmentioning

confidence: 99%

Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death

et al. 2018

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Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. The polyphenol-rich ethanolic extract obtained from the stem part of the plant C. scarabaeoides (EECs) was found to be efficient in killing the filarial nematode Setaria cervi in all the three developmental stages viz. oocytes, microfilariae (Mf) and adults with LD50 values of 2.5, 10 and 35 μg/ml, respectively. While studying the molecular mechanism of action, we found that induction of oxidative stress plays the key role in inducing the mortality in S. cervi. The redox imbalance finally results in activation of the nematode CED pathway that executes the death of the parasite. Intriguingly, EECs was found to be selectively active against the worm and absolutely non-toxic to the mammalian cells and tissues. Taken together, our experimental data demonstrate that C. scarabaeoides can be chosen as an affordable natural therapeutic for treating filarial infection in the future with high efficacy and less toxicity.

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Carbohydrate polymer inspired silver nanoparticles for filaricidal and mosquitocidal activities: A comprehensive view

Cited by 23 publications

References 55 publications

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Chitosan biopolymer functionalized gold nanoparticles with controlled cytotoxicity and improved antifilarial efficacy

Silver nanoparticles: Synthesis, medical applications and biosafety

Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death

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