The probability that a vaginal infection can interfere with fertility is often overlooked. The microorganisms, their products may inhibit sperm morphol-ogy and motility. Abnormal cervical mucus and sperm interactions clarify infertility in 5% to 10% of couples with a fertility problem. The aim of this research study was to estimate the prevalence of Gonococcal (IgG), Myco-plasma hominis (IgG) and Ureaplasma urealyticum (T. mycoplasma) (IgG) antibodies in unexplained infertile women having positive post coital test (PCT). Blood samples of 50 positive PCT identified infertile females and 50 healthy pregnant females (age group of 24-36 yrs) were collected and ana-lyzed for Gonococcal (IgG), M. hominis (IgG) and T. mycoplasma (IgG) anti-bodies by ELISA technique. In the study group patients, only 12 % cases (6/ 50) were positive for IgG gonococcal antibodies but no any positive case was found in control group. 28% cases (14/50) were found positive for M. homi-nis IgG antibodies in study group patients and only 10 % cases (5/50) were positive in control group. Results statistically were insignificant. In case of T. mycoplasma IgG antibodies, 76% (38/50) infertile women were observed as positive while only 24% (12/50) cases of control group were found positive for the same (p < 0.001). The results were not significant for gonococcal and M. hominis antibodies but were highly significant for U. urealyticum IgG an-tibodies and it was concluded that it may be a cause of infertility in positive PCT cases as no any other known reason of infertility is noticed in such cases.
Serum insulin level and insulin resistance are the prominent precursors of type 2 diabetes mellitus and HbA1c level correlates favorably with glycemic level. Obesity and dietary macronutrients also apparently play a role in this disease. Hence, insulin resistance, HbA1c, lipid profile and Magnesium level were evaluated in T2DM subjects categorized as having macro and micro-vascular complications and results were compared with controls. 200 sub-jects, grouped as- group I (50 normal healthy controls) ,Group- II (75 patients without any complication) and Group- III (75 patients having micro or macrovascular complications) were selected for this research study. We observed the fasting blood glucose level, serum HbA1c level, serum insulin level, insulin resistance, magnesium level and lipid profile in all group subjects. Significant increase in serum fasting glucose (p<0.001), insulin level (p<0.001) and re-sistance (p<0.001) was observed in both group II and Group III subjects when compared with control group. . HbA1c (%) level were recorded very high in both study group patients (p<0.01 and p<0.001). Serum magnesium level was measured and study group diabetic patients showed hypomagnesemia (p<0.01). Statistically highly significant value of Serum total cholesterol (p<0.001), triglyceride (p˂ 0.01) and LDL-C (p<0.001) were observed in both group subjects when compared with controls. Whereas statistically signifi-cantly decreases in serum HDLC (p<0.001) level were evaluated. Significant correlation coefficient with determination among diabetic group II and III patients and various biochemical parameters were evaluated. Hypomagnesemia and a higher level of cholesterol and TG values are responsible for macro-vascular changes in T2-DM.
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