Evaluation of pro-inflammatory cytokine level in cases of idiopathic recurrent spontaneous miscarriage in Saudi Arabia

Tyagi, Poonam; Alharthi, Nahed S.

doi:10.4103/bbrj.bbrj_71_20

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…Therefore in this regard, the current result is consistent with numerous earlier investigations [32,33,34]. This concordance, however, does not fit the IL-12 results in Group2, may be because different in study group.…”

Section: Age Groups and Study Groupssupporting

confidence: 78%

“…The generation of IFN-γ by interleukin-12 (IL-12) causes Th1 cells to differentiate. Because Th1-dependent processes are potentially involved in allograft rejection, researchers have revealed that Th1-type immunity may be detrimental during pregnancy, then an augmented Th1-type cytokine response may result in pregnancy loss [32], also according to a study K. Rezende-Oliveira, et al 2012, it was suggested that immunomodulation, which was observed during pregnancy, was involved in Toxoplasma gondii evading the immune response [33].…”

Section: Age Groups and Study Groupsmentioning

confidence: 99%

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The Correlation Between Toll-Like Receptor-5 Gene Polymorphism with Serum Level of Toll–Like Receptor-5 and Interleukin-6 and Interleukin-12 Response to Toxoplasma Gondii in Pregnant Women

Al-Baldawy¹,

Al-Marsomy²,

Kahleel³

2022

PJMHS

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Background: Toxoplasma gondii is an obligate intracellular parasite that can cause variable clinical symptoms or can even be asymptomatic in immunocompetent individuals. The parasite is known to cause congenital diseases, ocular, and miscarriage in pregnant women. Primary infections are dangerous in pregnant women, that occurring usually asymptomatically, especially in the first trimester. Different rates of pregnant women are infected with Toxoplasma gondii in different countries. Primary infections in pregnant women result in transmission of Toxoplasma. gondii through the placenta to the fetus and then in congenital infections, and it is not the only reason for miscarriage, the activity of Toll -like receptors in defense against Toxoplasma gondii infections was observed such as Toll-like receptor5 molecule, and some cytokines (such as IL-6, and IL-12 ), maybe lead to abortion. Several single-nucleotide polymorphisms (SNPs) residing in genes encoding these receptors were reported as significant genetic modifications of Toll- like receptors and correlated with miscarriage. Objectives : Study the correlation of TLR-5 gene polymorphism in pregnant women infected with toxoplasmosis, and study association of TLR-5 polymorphisms with the serum level of TLR-5 and cytokines (IL-6, IL-12) in pregnant women infected with toxoplasmosis. Methods: The present Case-control study was conducted on 100 women, of which fifty pregnant women seropositive (IgG, IgM) for Toxoplasma gondii (Group1), fifty pregnant women seronegative (IgG, IgM) for Toxoplasma gondii (Group2), as a control group, collected in the period from January 2021 to December 2021.

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Section: Age Groups and Study Groupssupporting

confidence: 78%

Section: Age Groups and Study Groupsmentioning

confidence: 99%

The Correlation Between Toll-Like Receptor-5 Gene Polymorphism with Serum Level of Toll–Like Receptor-5 and Interleukin-6 and Interleukin-12 Response to Toxoplasma Gondii in Pregnant Women

Al-Baldawy¹,

Al-Marsomy²,

Kahleel³

2022

PJMHS

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“…An increased IL-6 concentration in plasma [ 128 ] and serum [ 123 , 129 , 130 ], as well as greater expression in PBMCs [ 123 , 128 ], is found in SPL and RPL patients vs. controls. Unaltered [ 131 , 132 ] or decreased IL-6 levels in serum [ 133 , 134 , 135 , 136 ] of SPL and RPL patients are also shown. Similarly, unaltered [ 131 ], increased [ 133 , 136 ] and decreased [ 134 ] levels of IL-8 in PL patients are all reported.…”

Section: Il-6 and Il-8 In Selected Pregnancy Pathologiesmentioning

confidence: 99%

“…Unaltered [ 131 , 132 ] or decreased IL-6 levels in serum [ 133 , 134 , 135 , 136 ] of SPL and RPL patients are also shown. Similarly, unaltered [ 131 ], increased [ 133 , 136 ] and decreased [ 134 ] levels of IL-8 in PL patients are all reported. These inconsistent findings could be explained, at least in part, by the methodological differences between the studies (inclusion criteria for the participants, gestational age, inclusion of both SPL and RPL patients in the study, assigned control groups, etc.).…”

Section: Il-6 and Il-8 In Selected Pregnancy Pathologiesmentioning

confidence: 99%

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

Vilotić

Nacka-Aleksić

Pirković

et al. 2022

IJMS

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Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed.

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Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers

Singh,

Mandal,

Chauhan

et al. 2024

Toxicology Research

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Background Zearalenone (ZEA), a natural food contaminant, is reported to act as a mycoestrogen due to its estrogen-mimicking properties. According to studies, ZEA has a greater potential for estrogenic activity compared to any other naturally occurring non-steroidal estrogen. ZEA has been found in the endometrium of individuals with reproductive problems and the serum of children facing early puberty. These studies suggested a possible link between ZEA exposure and endometrial toxicity; nonetheless, no thorough research has been done. This study assessed the endometrium’s response to chronic ZEA exposure. Methods Four groups of CD-1 female mice were exposed to control, estradiol (E2), and two different doses of ZEA for 90 days. At the end of treatment, blood and uterus were collected, and samples were used for inflammatory cytokines level, immunochemical, histopathological, and biophysical analysis. Results Our data indicated that the uterus showed a change in body/organ weight ratio, while other organs did not have any notable changes. Immunochemical and histological studies showed hyperplasia and a higher number of glands in the endometrium after ZEA and E2 exposure. Similarly, proliferation markers such as proliferative cell nuclear antigen (PCNA), Ki-67, and inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and interferon-gamma (IFN-?) levels were found to be higher in the E2 and ZEA-exposed groups. Conclusion Our finding conclude that ZEA targets the uterus and cause inflammation due to increased levels of inflammatory cytokines and proliferation mediators, as well as systemic toxicity denoted by a strong binding affinity with serum proteins.

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Evaluation of pro-inflammatory cytokine level in cases of idiopathic recurrent spontaneous miscarriage in Saudi Arabia

Cited by 3 publications

References 41 publications

The Correlation Between Toll-Like Receptor-5 Gene Polymorphism with Serum Level of Toll–Like Receptor-5 and Interleukin-6 and Interleukin-12 Response to Toxoplasma Gondii in Pregnant Women

The Correlation Between Toll-Like Receptor-5 Gene Polymorphism with Serum Level of Toll–Like Receptor-5 and Interleukin-6 and Interleukin-12 Response to Toxoplasma Gondii in Pregnant Women

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers

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