The present research deals with preparation and evaluation of aceclofenac dental pastes containing extracted dillenia fruit gum (DG) for periodontitis treatment. Dental pastes containing 1% w/w aceclofeanc were prepared with/without using extracted DG as a mucoadhesive polymer via conventional trituration method. The drug contents, viscosities and pHs of these dental pastes were observed within the permissible ranges. The tube extrudability and tube spreadability of these pastes containing extracted DG were found favorable. The in vitro aceclofenac release from all these dental pastes was found slower sustained over 6 h, which followed zero-order kinetic model (R 2 = 0.9917-0.9988) with super case-II transport mechanism (n = 1.00-1.03). The in vitro aceclofenac release was found decreased with the viscosity increment of these dental pastes. These aceclofenac dental pastes containing extracted DG demonstrated excellent mucoadhesion onto excised porcine buccal mucosal membrane, which can be beneficial to get intimate contact with the action site during and after application to uphold the constant release of drugs over prolonged time. These dental pastes containing 1% w/w aceclofeanc can be applied for effective management of dental pain and inflammation with local delivery in the treatment of periodontitis.
Objective: The objective of the current work was to prepare and evaluate ex vivo skin permeation of cashew bark exudate gum based 4 % lidocaine HCl topical gels.Methods: In the current work, 4 % lidocaine HCl topical gels were prepared by using different concentrations of cashew bark exudate gum, HPMC K4M, lidocaine HCl, methyl paraben (as preservative) and glycerin (as plasticizer). The formulated topical gels were evaluated for pH, viscosity, and ex vivo skin permeation through excised porcine ear skin membrane.
Results:The pHs of these formulated 4 % lidocaine HCl topical gels were found within the range of 6.04±0.02 to 6.52±0.04; whereas, the viscosities were measured within the range, 4.38±0.02 x 10 6 to 4.74±0.04 x 10 6 cps. Sustained ex vivo permeation of lidocaine was measured over 7 h. Highest ex vivo permeation flux was measured when 0.1 % menthol was incorporated as a permeation enhancer. It was also higher than that of the marketed 4 % lidocaine HCl topical gel. The stability study by freeze thaw cycle method revealed physically stable gels without the occurrence of syneresis.
Conclusion:The results clearly indicate a promising potential of the use of cashew bark exudate gum as a gelling material with HPMC K4M to prepare 4 % lidocaine HCl topical gels of good skin permeation capability.
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