Stimuli-responsive carbon nanotubes for targeted drug delivery

Hasnain, M. Saquib; Syed, Anees A.; Hoda, Mohammad Niyaz; Rishishwar, Sanjay; Rishishwar, Poonam; Nayak, Amit Kumar

doi:10.1016/b978-0-08-101995-5.00015-5

Cited by 25 publications

(12 citation statements)

References 115 publications

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“…Thus, the application of CNTs in the pH-dependent release of anticancer drugs is another major advantage of their use in cancer drug delivery systems. It reduces side effects, increases drug circulation time and specificity, decreases administration frequency, and preserves the optimum drug concentration [76]. In this context, Gu et al developed the DOX and hydrazinobenzoic acid (HBA) functionalized SWCNT complex via hydrazine bonding and evaluated its cytotoxic effects on HepG2 cancer cells [77].…”

Section: Drug Targetingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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Cancer belongs to a category of disorders characterized by uncontrolled cell development with the potential to invade other bodily organs, resulting in an estimated 10 million deaths globally in 2020. With advancements in nanotechnology-based systems, biomedical applications of nanomaterials are attracting increasing interest as prospective vehicles for targeted cancer therapy and enhancing treatment results. In this context, carbon nanotubes (CNTs) have recently garnered a great deal of interest in the field of cancer diagnosis and treatment due to various factors such as biocompatibility, thermodynamic properties, and varied functionalization. In the present review, we will discuss recent advancements regarding CNT contributions to cancer diagnosis and therapy. Various sensing strategies like electrochemical, colorimetric, plasmonic, and immunosensing are discussed in detail. In the next section, therapy techniques like photothermal therapy, photodynamic therapy, drug targeting, gene therapy, and immunotherapy are also explained in-depth. The toxicological aspect of CNTs for biomedical application will also be discussed in order to ensure the safe real-life and clinical use of CNTs.

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Section: Drug Targetingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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“…Carbon nanotubes (CNTs) are carbon allotropes possessing a tube-like hollow cylindrical structure [35]. Based on the layer of the tubes, CNTs can be classified as either single-walled (SWNTs) (1 nm diameter) or multi-walled (MWNTs) (5 to 20 nm outer and 2 to 6 nm inner diameter) [35]. Raw CNTs are hydrophobic [36].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

“…Aromatic molecular drugs such as Doxorubicin can bind to the CNT surface through supramolecular π-π stacking [36,37]. Functionalized CNTs can act as carriers for various therapeutics (from small-molecules to peptides, to nucleic acids) and are able to deliver the active agents to various organs depending on the functionalization of the nanotubes, which may also be responsive to different stimuli [35,36,38].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Kang

2020

Pharmaceutics

136

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Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

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“…Currently, great attention is being given from researchers to nanoscale-based drug delivery systems for the treatment of cancerous cells, such as tunable prodrugs [8], polymeric micelles [9], inorganic nanoparticles [10], nanotubes [11], nanorods [12], dendrimers [13], lipid-based drug delivery systems [14] and carrier-based drug delivery systems [15]. Among the aforementioned drug delivery strategies, stimuli-responsive lipid-based drug delivery systems, nanocarriers and prodrugs as displayed in Figure 1, have attained the greatest attention.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

113

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The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.

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Stimuli-responsive carbon nanotubes for targeted drug delivery

Cited by 25 publications

References 115 publications

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

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