BackgroundThis study aimed to evaluate the patient's pain and quality of life after suture removal at either 3 or 7 days following the bilateral surgical extraction of impacted lower third molars.MethodsThis study was a prospective, randomized controlled clinical trial carried out in 30 patients, who acted as their own control. Each patient required the bilaterally impacted mandibular third molars to be extracted. The impacted teeth were removed and the wound margins were approximated and sutured with black braided silk. The suture material was removed on day 3 on one side and on day 7 on the other. Each participant was asked to complete a questionnaire after the removal of the suture material on each designated day.ResultsRegarding overall clinical symptoms, the mean VAS scores of male and female participants on day 3 were not significantly different from those on day 7. A significant difference was found in female participants, in that overall daily activity was better on day 7. There were significant differences in the ability to smile and laugh in both sexes and the ability to chew in the male participants was better on day 7.ConclusionsThere were no significant differences in the patient's pain and quality of life between suture removal on day 3 or on day 7 following surgery to remove impacted lower third molars.
Background The aim of this study was to compare periodontal conditions of the distal aspect of mandibular second molar and patient’s satisfaction between standard surgical technique and primary closure with or without distal wedge surgery used for the removal of mandibular third molar impaction (MTMI). Methods Twenty-four patients, aged 18 - 25 years, were invited to participate in this prospective, single-blinded, split-mouth randomized controlled study. Each participant owned similar bilateral impacted mandibular third molar. Periodontal parameters (i.e. probing depth (PD), gingival index (GI), plaque index (PI) and the distance from cusp tip to gingival margin (CT-GM)) were measured. The standard mandibular third molar surgery was performed on one side while for the other side the distal wedge surgery with or without osseous contouring was added to the protocol. Information about satisfaction was taken from questionnaire. Results At the site where distal wedge was performed, significant change in CT-GM occurred at all aspects and a significant PD reduction was observed at disto-buccal and mid-distal sites. Distance between cemento-enamel junction (CEJ) and gingival margin reduced significantly at all sites. No significant difference between two groups was found in GI, PI and patient’s satisfaction. Conclusions Incorporating distal wedge surgery into MTMI removal protocol does improve periodontal health of adjacent second molar and does not affect patient’s satisfaction.
In order to search for new anti-inflammatory agent for use as an adjunctive treatment for periodontal diseases, we have studied crude extracts from plants of family Rutaceae, Asteraceae and Maliaceae which have been claimed to possess anti-microbial and anti-inflammatory activities. The cytotoxic effect of these plant crude extracts on human gingival fibroblasts (HGFs) and monocytes was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Then, a non-cytotoxic dose was chosen for each plant extract and used to determine the anti-inflammatory activity. The enzyme linked to immunosorbent assay was used to assay tumor necrosis factor-alpha (TNF-) and interleukin-1beta (IL-1) released from cells treated with bacterial lipopolysaccharides (LPS). The results showed that the half maximal inhibitory concentration (IC 50) of plant extracts for HGFs were in the range of 308.12 to 1168.66 µg/ml while the IC 50 for macrophages were in the range of 54.6 to 90.92 µg/ml. Stem bark of Cratoxylum formosum demonstrated a comparable inhibitory activity to dexamethasone (DM) on TNF- production by both cells, but showed detectable reduction of IL-1 only in macrophages. Other plant extracts showed no significant difference for reduction of inflammatory cytokines from macrophages. Moreover, leaf and branch of Murraya paniculata showed greater inhibitory activity than DM on the production of TNF- from stimulated HGFs. Therefore, these plant extracts may be good candidates for further drug development for adjuctive treatment of periodontal diseases.
Almost nonexistent in the early '90s, herbal supplements market gained an important dimension to Romanians, with the growing awareness and the amounts that people are willing to pay for improving their health. Since this segment is difficult to monitor by market research companies, we propose in this paper a pleading in favor of increasing consumption of therapeutic and aromatic plant products, based on a holistic national approach. following a 10-year survey (period 2001-2010), we analyzed some specific statistical parameters, such as: top and value sales of dietary supplements in Romania; the average consumption of herbal supplements per capita; share of organic crop areas in the used agricultural area; the turnover of indigenous industry in harnessing the potential of ethnopharmacology; educational attainment by age group; death rates of chronic diseases; life expectancy at age 65; existence of data-bases accessible via internet as a useful tool for information and international promotion of Romanian medicinal plants (420 species); surveys on the treatment of diseases with natural products versus synthetic drugs. in conclusion, if 10 years ago herbal supplements market was almost insignificant, currently, the population shows flexibility in choosing products that are based on active natural substances, especially the social categories with high education and increased access to information. Even sales have tripled in the period 2008-2010, however remains an annual average consumption per capita of 9.5 euros, while in countries like Poland, Czech Republic or Slovakia values vary between 12-15 euros/capita, rising in Western Europe up to č25. Approximately 85 % of the raw material used by Romanian manufacturers comes from native flora. On education, health and life expectancy, these parameters improved over the studied period, the largest increase (25 %) occurring in the educational attainment of the 55-64 age group, which is also the age of onset of many chronic and degenerative diseases.Acknowledgement: This work was supported by a grant of the Romanian National Authority for Scientific Research, CNCS -UEfiSCdi, project number PN-ii-id-PCE-2011-3-0474. ANTI-INFLAMMATION EFFECT OF THAI HERBAL EXTRACTS FOR POTENTIAL ORAL USE © Rodanant Pirasut, Surarit Rudee, Sricha Rajporn, Korsuwanwong SuwannaFaculty of Dentistry, Mahidol University, Bangkok, Thailand This work describes studies on the crude extracts from plants of family Rutaceae, Asteraceae and Maliaceae, which have been claimed to possess anti-microbial and anti-inflammatory activity. Cytotoxicity of these extracts on human gingival fibroblasts (hGf) (CRl 2014) and monocytes (U937) were tested using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. in addition, TNf-α, il-1β and il-6 released from hGfs and monocytes treated with bacterial lipopolysaccharides (lPS) were determined using the enzyme-linked immunosorbent assay (EliSA). The results showed that the iC 50 of plant extracts for hGfs were in the range of 308.1 to 1168...
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