Cytotoxic and anti-inflammatory activity of some Thai medicinal plants

Rodanant, Pirasut

doi:10.5897/jmpr12.644

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…The inhibition of LOX and COX by these extracts could contribute to reducing the increased release of pro-inflammatory cytokines (Il-1β, Il-6, IL-10, TNFα, INFγ, PGE2, etc.) as well as metalloproteinases (MMPs) [40,41].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

The Potential of Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica Traditional Plants From Burkina Faso in Treating Periodontitis: A Systematic Review

Diarra,

Agossa,

Youl

2024

Cureus

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Periodontitis is a chronic, infectious, and inflammatory oral disease with a high prevalence in developing countries, where limited access to modern dental care curtails its treatment. This review is dedicated to examining three indigenous botanical species frequently recommended by traditional therapists for the treatment of periodontal disease, namely, Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica, with the aim of elucidating their chemical constituents and pharmacological properties that may support their empirical use. This review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines extension for scoping reviews. An electronic search was conducted in three databases (PubMed, Science Direct, and Google Scholar) up to July 2022. Out of 700 articles initially identified, only 11 were deemed eligible for inclusion; a substantial majority (80%) of these comprised in vitro studies. Among the trio of botanicals considered, Waltheria indica emerged as the most extensively investigated (65% of the studies). The administration of these plants was predominantly in the form of decoctions or macerations, with extraction methods employing alcoholic agents (ethanolic and methanolic), hydroalcoholic solutions, or aqueous solvents.The selected plants exhibited notable richness in polyphenolic compounds, particularly flavonoids, and demonstrated anti-inflammatory effects, as indicated in 60% of the studies, along with antibacterial properties (against Streptococcus aureus and Helicobacter pylori). None of the studies reported antibacterial activity against periodontal pathogens.The pharmacological properties of these plants may hold promise for the management of oral inflammatory and infectious conditions. Nevertheless, further comprehensive investigations are imperative to establish their safety and efficacy for periodontitis treatment before conclusive recommendations can be formulated.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

The Potential of Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica Traditional Plants From Burkina Faso in Treating Periodontitis: A Systematic Review

Diarra,

Agossa,

Youl

2024

Cureus

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“…Inhibiting L.O.X. by the extracts could help decrease the increased release of proinflammatory cytokines (Il-1β, Il-6, IL-10, TNFα, INFγ, PGE2...), and several metalloproteinases due to dental inflammation 32 .…”

Section: Anti-biofilm Effect Of Extractsmentioning

confidence: 99%

Therapeutic properties of aqueous extracts of leaves and stems bark of Prosopis africana (Guill. & Perr.) Taub. (Fabaceae) used in the management of dental caries

Bancé

Sourabie

Compaoré

et al. 2021

J. Drug Delivery Ther.

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Prosopis africana (Guill. & Perr.) Taub. (Fabaceae) is used in the herbal medicine of Burkina Faso to treat dental caries. This study aims to contribute to the valorization of the said plant by investigating the antioxidant, anti-inflammatory and antibacterial properties of aqueous leaves and stems extracts. The inhibitory activity on lipoxygenase was used to evaluate the anti-inflammatory effect of the extracts. The antioxidant activity of bots extracts of the plant was assessed using DPPH radical scavenging, ABTS+ radical cation decolorization. The anti-biofilm effect of the extracts was evaluated on Streptococcus mutans ATCC 25175, Staphylococcus aureus ATCC 43300, Pseudomonas aeruginosa PAOI and the anti-Quorum sensing effect on Chromobacterium CV026. Aqueous extracts of Prosopis africana stems show the highest content of phenolic compounds (30,04± 0,59 mgAGE/100 mg extract) while those of the leaves show the highest content of total flavonoids (3.29 ± 0.53 mgQE/100mg extract). The aqueous extract of stem bark show the strongest antioxidant activity ( IC50 = 4.58±0.07µg/ml for the ABTS) , a best Inhibitory action on activity of lipoxygenase (IC50 = 13.42 ± 1.26 μg/mL ), a highest anti-biofilm activity ( 63.6%; at the concentration of 100µg/ml) without affecting the bacterial growth. In addition, this extract has the strongest anti-quorum sensing activity with an percentage of inhibition 53,5%. These findings suggested that the aqueous extracts of stem bark and leaves of Prosopis africana contain promoted phytomolecules to combat dental caries infections. Keywords : Anti-biofilm, Anti-quorum sensing, Lipoxygenase, Prosopis africana

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“…Rodanant et al mentioned that the dichloromethane extract of C. odorata leaves showed the cytotoxic effect against human gingival fibroblasts cells (HGFs) and monocyte cell lines (U937) using MTT assay with IC 50 values of 461.59 and 64.07 µg/ml, respectively [141]. Yajarla et al studied the anti-proliferative property on a skin cancer cell line (A431).…”

Section: Mtt Cell Viability Activitymentioning

confidence: 99%

Standardization of Chromolaena Odorata, Kaempferia Parviflora and Zanthoxylum Piperitum

Pitakpawasutthi

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Chromolaena odorata (L.) R.M. King & H. Rob. or Sabsue is a species in family Asteraceae. In Thailand, it is locally used to treat skin diseases, diabetes, as well as insect bites. Kaempferia parviflora Wall. ex Baker or Krachai Dum belongs to Zingiberaceae family. In herbal medicine, it is generally used to promote health, to cure gastrointestinal disorder and anti-inflammation. Zanthoxylum piperitum (L.) DC., belonging to the Rutaceae family, is known in Thai name as Prig Horm. All parts of Z. piperitum are used to treat abdominal pain, vomiting and diarrhea. Chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin are the active components in C. odorata leaves, K. parviflora rhizomes and Z. piperitum fruits respectively and these compounds were used as a standard marker in this study. For quantitative analysis, the results indicated that the chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin contents quantified by TLC-densitometry and TLC image analysis were not statistically significantly different (P > 0.05). For in vitro biological activities, the results revealed that each extract and its active constituents showed its antioxidant and anti-diabetic potentials. K. parviflora rhizome showed potent toxicity whilst C. odorata leaf and Z. piperitum fruit ethanolic extract showed weak toxicity against brine shrimp nauplii. As the result of cell viability activity, all tested samples exhibited no significant cytotoxic activity against 5 human cancer and 1 normal cell lines. For GC-MS analysis, each plant samples showed its major components of essential oil. Furthermore, the pharmacognostic specification of K. parviflora rhizomes were established in order to provide macroscopic and microscopic evaluation, physico-chemical parameters and chemical fingerprints.

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Cytotoxic and anti-inflammatory activity of some Thai medicinal plants

Cited by 3 publications

References 28 publications

The Potential of Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica Traditional Plants From Burkina Faso in Treating Periodontitis: A Systematic Review

The Potential of Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica Traditional Plants From Burkina Faso in Treating Periodontitis: A Systematic Review

Therapeutic properties of aqueous extracts of leaves and stems bark of Prosopis africana (Guill. & Perr.) Taub. (Fabaceae) used in the management of dental caries

Standardization of Chromolaena Odorata, Kaempferia Parviflora and Zanthoxylum Piperitum

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