The T
1–T
2 dual-mode contrast
agents for magnetic resonance imaging
(MRI) can generate self-complementary confirmed T
2 and T
1 images, hence greatly
improving the reliability. Facilely synthesizing nanoparticles with
the ultrasensitive contrast property remains extremely challenging
in nanoscience. Moreover, uncovering the mechanism correlating the
signal enhancements and chemical constituents is vital for designing
novel efficient synergistically enhanced T
1–T
2 dual-mode MRI nanoprobes.
Herein, we report a one-pot facile method to synthesize the superparamagnetic
manganese oxide-doped iron oxide (Fe3O4/MnO)
nanoparticles for T
1–T
2 dual-mode MR imaging. Under external magnetic field,
the local magnetic field intensities of MnO and Fe3O4 could be simultaneously enhanced through embedding MnO into
Fe3O4 nanoparticles and hence can cause synergistic T
1 and T
2 contrast
enhancements. Moreover, a novel and facile cost-effective method for
large-scale synthesis of hydroxyl–polyethylene glycol–phosphonic
acid-stabilizing ligands is designed. The facile synthetic method
and surface coating strategy of superparamagnetic Fe3O4/MnO nanoparticles offer an idea for the chemical design and
preparation of superparamagnetic nanoparticles with ultrasensitive
MRI contrast abilities for disease evaluation and treatment.
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