Controllable synthesis of exceptionally small-sized superparamagnetic magnetite nanoparticles for ultrasensitive MR imaging and angiography

Abstract

The superparamagnetic iron oxide nanoparticles have broad application prospects in the diagnosis and treatment of cancer.

Facile synthesis of superparamagnetic nickel-doped iron oxide nanoparticles as high-performance T1 contrast agents for magnetic resonance imaging

“…The blocking temperatures at the peak of the FC/ZFC curves of NiIO NPs were all below 125 K, which was attributed to the extremely small size of nanoparticles. 14,39,40…”

“…Recent studies have shown that small-sized IONPs have great potential as an alternative to substituting GBCAs. 7,10,14–21 Nanoparticles smaller than 10 nm have a strong diffusion ability and can penetrate deeply into tumor tissue. 22,23 However, compared with those of GBCAs, the relaxation effectiveness and contrast enhancement of T 1 were not significant.…”

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

“…Inorganic nanostructures with different mechanical and physical properties can be employed in different applications such as medicine, electronic device, sunscreens, military applications, photovoltaic cells, paints, catalysts, and among others 8 – 16 . Among nanostructures, nanofibers are defined as structures with an outer diameter below 1000 nm 17 , 18 .…”

Improving the sensitivity of T1 contrast-enhanced MRI and sensitive diagnosing tumors with ultralow doses of MnO octahedrons

“…On the other hand, ultrasmall iron oxide NPs as T 1 CAs attract lots of attention due to their suppressed magnetization by the strong surface spin-canting effect 17 , 18 . There are also many excellent surface ligand modifications, such as phosphoric acid anchoring group, carboxyl anchoring group, and catechol anchoring group can can avoid the dissolution and oxidation of ultrasmall iron oxide NPs into Fe ions in biological media 19 - 21 . However, ultrasmall iron oxide NPs are usually ultrasmall spheres and not easy for further shape engineering and investigating.…”