ABSTRAKWanita dengan obesitas akan mengalami penambahan lemak, lemak ini akan terakumulasi pada lemak viseral yang jika menumpuk pada waktu lama akan menyebabkan terjadinya PCOS sehingga menyebabkan menstruasi tidak teratur dan anovulasi. Tujuan penelitian ini adalah untuk mengetahui gambaran mengenai faktor yang dapat menyebabkan hambatan wanita dengan obesitas untuk merubah life-style sehingga berisiko mengalami PCOS serta untuk mengembangkan instrumen edukasi untuk menurunkan risiko pcos pada wanita dengan obesitas. Penelitian ini terdiri dari tiga tahap. Pada tahap pertama dilakukan penilaian kebutuhan edukasi wanita obesitas dengan metode kualitatif menggunakan wawancara semi terstuktur. Pada tahap kedua dilakukan pengembangan instrumen edukasi dan dilakukan pembuatan kuisioner pengetahuan. Pada tahap ketiga dilakukan evaluasi awal terhadap instrumen edukasi. Faktor yang mempengaruhi menyebabkan hambatan wanita obesitas untuk merubah life-style, antara lain: Faktor yang berhubungan dengan pasien dan faktor diluar pasien (lingkungan). Sebagian besar pengetahuan pasien terhadap penyakit dan pengobatan kurang sehingga menyebabkan persepsinya salah dan pasien menjadi tidak patuh Bentuk instrumen edukasi yang dibutuhkan adalah instrumen untuk mengubah pengetahuan pasien, berupa booklet edukasi. Booklet edukasi yang dikembangkan diharapkan dapat meningkatkan pengetahuan sehingga pada akhirnya dapat mengubah perilaku ketidakpatuhan pasien pada penelitian lebih lanjut. ABSTRACTWomen with obesity would experience an increase in lipid. These lipids would be accumulated in the visceral part of the body caused anovulation that is part of the menstrual disorder called polycystic ovary syndrome (PCOS). This study aims to know factors that could affect obese women to change their lifestyle and to develop an instrument to educate obese women to decrease the risk of PCOS. This study consisted of three steps. In the first step, the obese woman was evaluated qualitatively using semi-structured interviews to know their education needs. In the second step, the education instrument was developed based on their
Endometriosis is a gynecological disease associated with inherited genetic traits. HOXA10 gene which is expressed in uterine plays an important role in the pathogenesis of endometriosis. The protein affects the development of pinopodes as a biomarker of endometrial receptivity in endometriosis.The aim of this study is to examine if there is a mutation or polymorphism within HOXA10 gene among patients with endometriosis. Thirty twopatients and 32 healthy women were recruited as subjects of this study. The exon 2 of HOXA10 which covers most of coding region was amplifi ed using PCR. The presence of a mutation or polymorphism was detected by direct seguencing. The distribution of genotype and allele was analyzed using Chi square test with p<0.05 is considered as signifi cantly different. A novel heterozygous variant within exon 2 of HOXA10 which substitute an adenine into thymine was detected at base position 55. This missense alteration changed amino acid serine to cystein (Ser19Cys). Interestingly, this variant was detected in 12 endometriosis cases (38%) but none in control. Patients carry HOXA10 Ser19Cys variant were associated with dismenorea and more frequent in stage I endometriosis. The role of this variant in the function of HOXA10 protein and frequency among Indonesians need to be clarifi ed. We found a novel heterozygous HOXA10 gene variant, Ser19Cys.The genotype frequency is 38% among endometriosis patients but none in control. This variant found in patient with dismenore and endometriosis stage 1.
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