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In the practical radar with multiple antennas, the antenna imperfections degrade the system performance. In this paper, the problem of estimating the direction of arrival (DOA) in multiple-input and multiple-output (MIMO) radar system with unknown mutual coupling effect between antennas is investigated. To exploit the target sparsity in the spatial domain, the compressed sensing (CS)-based methods have been proposed by discretizing the detection area and formulating the dictionary matrix, so an off-grid gap is caused by the discretization processes. In this paper, different from the present DOA estimation methods, both the off-grid gap due to the sparse sampling and the unknown mutual coupling effect between antennas are considered at the same time, and a novel sparse system model for DOA estimation is formulated. Then, a novel sparse Bayesian learning (SBL)-based method named sparse Bayesian learning with the mutual coupling (SBLMC) is proposed, where an expectationmaximum (EM)-based method is established to estimate all the unknown parameters including the noise variance, the mutual coupling vectors, the off-grid vector and the variance vector of scattering coefficients. Additionally, the prior distributions for all the unknown parameters are theoretically derived. With regard to the DOA estimation performance, the proposed SBLMC method can outperform state-of-the-art methods in the MIMO radar with unknown mutual coupling effect, while keeping the acceptable computational complexity.

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High-resolution measurement of membrane capacitance in the whole-cell-recording configuration can be used to detect small changes in membrane surface area that accompany exocytosis and endocytosis. We have investigated the noise of membrane capacitance measurements to determine the fundamental limits of resolution in actual cells in the whole-cell mode. Two previously overlooked sources of noise are particularly evident at low frequencies. The first noise source is accompanied by a correlation between capacitance estimates, whereas the second noise source is due to "1/f-like" current noise. An analytic expression that summarizes the noise from thermal and 1/f sources is derived, which agrees with experimental measurements from actual cells over a large frequency range. Our results demonstrate that the optimal frequencies for capacitance measurements are higher than previously believed. Finally, we demonstrate that the capacitance noise at high frequencies can be reduced by compensating for the voltage drop of the sine wave across the series resistance.

NMR is routinely used to quantitate chemical species. The necessary experimental procedures to acquire quantitative data are well-known, but relatively little attention has been applied to data processing and analysis. We describe here a robust expert system that can be used to automatically choose the best signals in a sample for overall concentration determination and determine analyte concentration using all accepted methods. The algorithm is based on the complete deconvolution of the spectrum which makes it tolerant of cases where signals are very close to one another and includes robust methods for the automatic classification of NMR resonances and molecule-to-spectrum multiplets assignments. With the functionality in place and optimized, it is then a relatively simple matter to apply the same workflow to data in a fully automatic way. The procedure is desirable for both its inherent performance and applicability to NMR data acquired for very large sample sets.