COVID-19 pandemic impacted human health and the global economy. There is a huge uncertainty about the management of this disease, many drugs including some older drugs are being tested for efficacy and safety including the medicines from the complementary and alternative system. The Central Council for Research in Ayurvedic Sciences, India's apex body for Ayurvedic research and development under the Ministry of AYUSH, has developed a poly-herbal drug called AYUSH 64 for covid 19 which is considered to be having role in the COVID-19. This study was designed with the aim of assessing the efficacy and safety of AYUSH 64 in mild covid-19 patients as add on therapy with standard treatment.
It was an open labelled, comparative, parallel group, Randomized controlled clinical trial. Total 60 stage I (mild) COVID 19 positive subjects were recruited, 30 were assigned to AYUSH 64 as an add on therapy along with the standard treatment and 30 were assigned to standard treatment as per the protocols. RT-PCR test was done as per government guidelines and protocol. Along with the RT-PCR clinical laboratory tests were also performed at screening as well as on the discharge as per the study schedule.
Absolute events of negative RT-PCR at day 5 were more in the AYUSH 64 group as compared to control group but it was not statistically significant (70% Vs 54%, p=0.28). There was no significant difference between AYUSH 64 and control group for fever and respiratory symptoms or important lab parameters. No serious adverse event was reported from any group.
AYUSH 64 has no significant beneficial effect as compared to control group, this may be because of the less sample size or no actual effect which need to be confirmed by studies with large sample size.
Introduction:Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These modalities have their own limitations and side effects apart from being expensive. There is a need for safer and cost effective antithrombolytic agents.Aim:To evaluate in vitro thrombolytic property of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.) plant extract.Materials and Methods:Venous blood drawn from 20 healthy volunteers was allowed to form clots which was weighed and treated with the extract of test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis. SK was used as a positive and water as a negative control.Statistical Analysis Used:The significance between % clot lysis of five groups by means of weight difference was tested by the one-way ANOVA.Results:Clot lysis observed were 68.06%, 14.85%, 25.01%, 92.54%, and 3.00% for Dhamasa, Kushta, Guduchi, SK, and distilled water, respectively.Conclusion:Herbal extracts possess thrombolytic properties and lyse blood clots in vitro.
Āyurveda is an oldest system of medicine practiced ini various parts of India and Indian sub continents. In today's era due to lack of physical activity, altered food habits, pollution, chemical exposure, number of skin disease has increased. In Āyurveda classics skin diseases are described under ones broad term called kuṣṭha, which is further categorized into two major groups i.e. Mahākuṣṭha and Kṣudrakuṣṭha. The study aimed to find out the prevalence and nidāna of Kuṣṭha (Skin diseases) in the local community. A survey study was conducted at NIA O.P.D, I.P.D., Bombaywala hospital, Satellite hospital, and various camps in Jaipur. For this survey total 200 skin disease patients were taken and diagnosed as per Āyurvedika perspective and Psoriasis criteria. Observations of the study are presented in graph 1 to 12 according to various profile. Kuṣṭha mainly affects in middle age group as the busy schedule and faulty dietary habits might contribute in the pathogenesis of disease. The disease is chronic in nature and bear strong family history and is affected by mental stress. Vāta-Kapha Prakṛti is more prone to be affected by the disease and intake of excessive amount of lavaṇa ras may contribute in the disease formation or aggravation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.