In vitro thrombolytic activity of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.)

Abstract

Introduction:Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These modalities have their own limitations and side effects apart from being expensive. There is a need for safer and cost effective antithrombolytic agents.Aim:To evaluate in vitro thrombolytic property of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.) plant extract.Materials and Methods:Venous blood drawn from 20 healthy volunteers was allowed to form clots which was weighed and treated with the extract of test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis. SK was used as a positive and water as a negative control.Statistical Analysis Used:The significance between % clot lysis of five groups by means of weight difference was tested by the one-way ANOVA.Results:Clot lysis observed were 68.06%, 14.85%, 25.01%, 92.54%, and 3.00% for Dhamasa, Kushta, Guduchi, SK, and distilled water, respectively.Conclusion:Herbal extracts possess thrombolytic properties and lyse blood clots in vitro.

Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model

“…Fagonia cretica has been described for hepatoprotective [ 26 ], antipyretic [ 27 ], antidiabetic [ 28 , 29 ], and hematological [ 30 ] properties. Fagonia arabica has been reported for its thrombolytic [ 31 ] and antioxidant activities [ 32 ]. Few other members such as Fagonia schweinfurthii and Fagonia bruguieri have revealed anti-inflammatory and antioxidant activities against hepatic injury [ 28 , 33 ].…”

Ex Vivo Antiplatelet and Thrombolytic Activity of Bioactive Fractions from the New-Fangled Stem Buds of Ficus religiosa L. with Simultaneous GC-MS Examination

“…Experimentations for clot dissolutions and antithrombotic action of fractions CFFR and MFFR from ethanol extract of F. religiosa new-fangled stem buds, and standard drug Streptokinase (SK) was carried out. Different concentrations (5,10,15,20,25,30,35, and 40 µg/mL) of test samples (CFFR and MFFR) were incorporated to clean microcentrifuge tubes holding 0.5 mL of blood in all tube no. 2-8.…”

“…The tested samples were incorporated just after clot formation. All reactions were sustained at 36 ± 2 • C and all the samples of each concentration were tested 3 times [24,25].…”