Lingual thyroid is a rare developmental disorder and is more frequent in women. The pathogenesis is unclear but may be related to the presence of maternal blocking autoantibodies against the thyroid. Treatment of this disorder includes the use of levothyroxine in order to correct the hypothyroidism, which is very frequent and to induce the shrinkage of the gland. When symptoms of obstruction or bleeding appear, ablative therapy by means of surgery or radioiodine is warranted. We report three cases and discuss the approach to diagnosis and a strategy for management.
Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.
BACKGROUND: Polyphenols are a group of compounds distributed in foods of plant origin and have been considered as effective protective agents against chronic diseases. To date, there are limited data on polyphenol intakes worldwide. OBJECTIVE: The aim of the present study was to describe the intake of polyphenols and their subclasses in Chile based on data extracted from the National Food Consumption Survey 2010 –2012 (ENCA). METHODS: A total of 3658 participants were selected from whom information on food consumption frequency, anthropometric, clinical, socioeconomic and lifestyle variables were available. RESULTS: The mean intake value of total polyphenols was 979.5 + 695.5 mg/day. A higher intake was observed in men than in women. In addition, among adults, there is a higher consumption in the South macrozone. An increase in the intake of total polyphenols was evidenced when the population belonged to the high socioeconomic stratum, and the most consumed types were flavonoids and phenolic acids. CONCLUSION: Due to the growing evidence that shows a protective effect of polyphenol consumption, it is necessary to carry out more research related to the consumption of these compounds, promoting the consumption of foods that provide them and thus contributing to improve the current epidemiological.
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