Flexible perovskite based solar cells with power conversion efficiencies of 7% have been prepared on PET based conductive substrates. Extended bending of the devices does not deteriorate their performance demonstrating their suitability for roll to roll processing

BackgroundThe clinical phenotype of CDH1 pathogenic variant carriers has mostly been studied in families that fulfil criteria of hereditary diffuse gastric cancer (HDGC). We aimed at determining cancer phenotype and cancer risk estimation among families with CDH1 pathogenic variants not selected by HDGC clinical criteria.MethodsPatients were all consecutively identified CDH1 pathogenic variant carriers from a clinical laboratory tested with multigene panel testing and from an academic cancer genetics programme. Clinical and demographic features, cancer phenotypes and genotype–phenotype correlations were determined among CDH1 families. Age-specific cumulative cancer risks (penetrance) were calculated based on 38 families with available pedigrees.ResultsWithin the 113 CDH1 pathogenic variant probands and 476 relatives, 113 had gastric cancer, 177 breast cancer and 196 other cancers. Mean age at diagnosis was 47 for gastric and 54 for breast cancer. Forty-six per cent fulfilled criteria of HDGC. While 36% of families had both gastric and breast cancers, 36% had breast but no gastric cancers and 16% had gastric but not breast cancers. Cumulative risk of cancer by age 80 was 37.2% for gastric and 42.9% for breast cancer.ConclusionIn unselected CDH1 pathogenic variant carrier families, gastric cancer risks were lower and age at diagnosis higher than previously reported in families pre-selected for HDGC criteria. A substantial proportion of families did not present with any gastric cancers and their cancers were limited to breast. Thus, clinical criteria for CDH1 testing should be widened, including breast cancer families only, and a consideration for delayed prophylactic gastrectomy/surveillance should be evaluated.

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A simple lamination technique for conductive and semitransparent fabrics on top of organic photovoltaic cells is presented. Conductive fabrics consisted of metal wires woven in a fabric with polymeric fibers. The lamination of this conductive fabric with help of a high conductive poly(3,4- ethylenedioxythiophene) polystyrene sulfonate formulation results in well aligned low resistive metal wires as top electrode. Semitransparent flexible organic photovoltaic cells were processed with laminated fabrics as top electrode and sputtered layers of aluminum doped zinc oxide and Ag as bottom electrode. The organic photovoltaic cells showed similar performance when illuminated through the bottom or top electrode. Optical simulations were performed to investigate light scattering effects of the fabric. Results are very promising for photovoltaic and lightning devices as well as for all kinds of devices where semitransparent, highly conductive, and non-vacuum processed electrode materials are needed