We found a high prevalence of HPV DNA in breast cancer. There is strong evidence to suggest that HPV has an important role in the development of breast cancer.

The events leading to preterm birth are still not completely understood. A quantitative systematic review was performed to estimate the effects of periodontal care during pregnancy on preventing preterm birth and low birth weight. The meta-analysis included randomized trials with pregnant women with a diagnosis of periodontal disease before 20 weeks of gestation. Relative risk (RR) with 95% confidence intervals (95%CI) was calculated. We evaluated the reduction in preterm and low birth weight. Thirteen trials were included, comparing 3,576 women in intervention groups with 3,412 women receiving usual care. The meta-analysis of the effects of periodontal disease treatment during pregnancy indicated a non-significant reduction in preterm births (RR = 0.90; 95%CI: 0.68-1.19) and low birth weights (RR = 0.92; 95%CI: 0.71-1.20). The creation and examination of a funnel plot revealed clear evidence of publication bias. In summary, primary periodontal care during pregnancy cannot be considered an efficient way of reducing the incidence of preterm birth.

Dynamic contrast-enhanced breast magnetic resonance (MR) is a promising emerging technique for evaluating breast lesions. A quantitative systematic review was performed to estimate the accuracy of breast MR in the diagnosis of high-risk breast lesions and breast cancer. A comprehensive search of the Cochrane Library, MEDLINE, CANCERLIT, LILACS, and EMBASE databases was performed from January 1985 to August 2010. The medical subjects heading (MeSH) and text words for the terms "breast neoplasm", "breast lesions", "breast cancer" and "magnetic resonance" were combined with the MeSH term diagnosis ("sensitivity and specificity"). Studies that compared breast MR with paraffin-embedded sections parameters for the diagnosis of breast lesions (benign, high-risk borderline, and breast cancer) were included. Sixty-nine studies were analyzed, which included 9,298 women with 9,884 breast lesions. Interrater overall agreement between breast MR and paraffin section diagnosis was 79% (κ = 0.55), indicating moderate agreement. Pooled sensitivity and specificity were 90% [95% CI 88-92%] and 75% [95% CI 70-79%], respectively. The pooled likelihood positive ratio was 3.64 (95% CI 3.0-4.2) and the negative ratio was 0.12 (95% CI 0.09-0.15). For breast cancer or high-risk lesions versus benign lesions, the AUC was 0.91 for breast MR and the point Q* was 0.84. In summary, breast MR is a useful pre-operative test for predicting the diagnosis of breast lesions.

RESUMOPessoas com deficiência são indivíduos que apresentam algum desvio de normalidade, podendo ser de ordem física, mental, sensorial, comportamental e/ou de crescimento, e que necessitam de cuidados diferenciados por um determinado período de tempo ou por toda a vida. Estudos que analisam o perfil epidemiológico de saúde bucal dos pacientes com necessidades especiais indicam alta prevalência de alterações como: cárie, edentulismo, traumatismo e de doença periodontal decorrente de uma higiene bucal precária. O objetivo deste estudo foi identificar a prevalência de alterações bucais em pacientes com necessidades especiais, atendidos na clínica de odontologia da Universidade do Extremo Sul Catarinense. Foi caracterizado como um estudo transversal, descritivo e quali-quantitativo, totalizando uma amostra de 73 prontuários de pacientes com idade entre 1 e 70 anos, predominantemente portadores de transtorno do espectro autista (23,3%). A pesquisa constatou que 68,1% dos pesquisados apresentaram acometimento de cárie, 55,6% de ausências dentárias e 50% de tártaro. Concluiu-se que alterações bucais podem ser prevenidas ou minimizadas, através do trabalho da equipe multidisciplinar no manejo do paciente portador de necessidade especial e programa de prevenção em saúde bucal. Descritores: Patologia • Saúde bucal • Pessoas com deficiência • Pacientes AbstractPersons with disability are individuals who have some normality deviation that can be physical, mental, sensory, behavioral and/or growth, which need special care for a certain period of time or for life. Studies that analyze the epidemiology of oral health of patients with special needs indicate high prevalence of alterations such as caries, tooth loss, trauma and periodontal disease resulting from a poor oral hygiene. The aim of this study was to identify the prevalence of oral abnormalities in patients with special needs attended at the dental clinic of UNESC. It was characterized as a cross-sectional, descriptive, qualitative and quantitative study, with a total sample of 73 records, ages from 1 to 70 years old, predominantly carriers of the autism spectrum (23.3%). The survey found that 68.1% of respondents had caries involvement, 55.6% dental absences and 50% tartar. It was concluded that oral diseases can be prevented or minimized through the work of the multidisciplinary team in the management of patients with special need, and prevention program in oral health. Descriptors: Pathology • Oral health • Disabled persons • Patients.

A presença de dentes supranumerários pode causar alterações funcionais e estéticas, principalmente quando localizados na região anterior da maxila, contando, ainda, com complicações na erupção do elemento dental permanente da área afetada. São definidos como dentes de desenvolvimento anormal que podem ocorrer tanto na dentição decídua como na dentição permanente, podendo ser únicos ou múltiplos, uni ou bilaterais permanecer impactados ou erupcionar na cavidade bucal e a sua etiologia permanece ainda desconhecida. A prevalência varia entre 0,8% e 3,7%, em diferentes estudos apresentados, sendo que o sexo masculino é o gênero mais prevalente. Frequentemente eles são diagnosticados em exames de rotina, uma vez que, na maior parte dos casos, são assintomáticos. Quando diagnosticados, a remoção cirúrgica está indicada para que o mesmo não venha causar interferência na dentição permanente. Este artigo apresenta o relato do caso de uma criança de 08 anos de idade que apresentava um dente supranumerário na região dos incisivos centrais superiores e o tratamento realizado foi a exodontia e, posteriormente, tratamento ortodôntico preventivo.

Background: As with other complications of diabetes mellitus, the occurrence of dry mouth can lead to a poor quality of life. Therefore, this study aimed to identify the prevalence of xerostomia in patients with diabetes mellitus through a systematic review and meta-analysis. Method: Systematic review and meta-analysis.Results: After the screening process, 23 studies were included in the meta-analysis. Overall, the incidence of dry mouth was investigated in 1979 people with diabetes (cases) and 1225 controls. The global prevalence of diabetes in xerostomia was 42.22% (95% CI: 33.97%-50.92%). In the analysis by specific subtype, the overall prevalence was 37.42% (95% CI: 22.33%-55.44%) among individuals with Type 1 diabetes and 46.09% (95% CI: 23.99%-69.85%) among those with type 2 diabetes. The prevalence of xerostomia found in Asia (49.01%; 95% CI: 32.08%-66.16%) was higher than that found in Europe (40.04%; 95% CI: 29.58%-51.50%) and America (38.39%; 95% CI: 23.63%-55.65%). Analysis of the case-control studies showed a statistically significant association between xerostomia and diabetes mellitus (OR=3.15; 95% CI: 2.11-4.70; p<0.001).

ObjectiveTo establish the diagnostic accuracy of magnetic resonance imaging (MRI) as an auxiliary means for the diagnosis of oral cancer through a systematic review and meta-analysis. MethodsAn exhaustive search of publications from 1986 to 2016 was performed of Medline, Embase and Cochrane (and related databases), including grey literature. Primary diagnostic accuracy studies that assessed oral cancer (target condition) using MRI (index test) were included. Diagnostic threshold, sensitivity and meta-regression analyses were performed. A meta-analysis was performed using Meta-DiSc® v. 1.4 software. ResultsA total of 24 primary studies were assessed, comprising 1,403 oral cancer lesions. Nine studies used diffusion-weighted MRI, with a diagnostic odds ratio (DOR) of 30.7 (95% confidence interval [CI]: 12.7-74.3) and area under the curve (AUC) of 0.917 (95% CI: 0.915-0.918); seven studies used dynamic contrast-enhanced MRI, with a DOR of 48.1 (95%CI: 22.4-103.2) and AUC of 0.936 (95% CI: 0.934-0.937); and 13 studies used traditional MRI, with a DOR of 23.9 (95%CI: 13.2-43.3) and AUC of 0.894 (95% CI: 0.894-0.895). Metaregression analysis indicated that the magnetic field strength may have influenced the heterogeneity of the results obtained (p = 0.0233) using traditional MRI. Sensitivity analysis revealed a discrete reduction of inconsistency in some subgroups. ConclusionThe three types of MRI assessed exhibited satisfactory accuracy compared to biopsy. Considering the relevance of early treatment and screening and that better health care results in PLOS ONE | https://doi

ResumoO presente estudo realizou uma revisão bibliográfica de frenectomia labial maxilar através da busca de artigos científicos no banco de dados do MedLine, Scielo, PubMed e Science Direct e um relato de caso de uma paciente do gênero feminino com 17 anos, sem alteração de saúde sistêmica, que compareceu à Clínica de Odontologia da Universidade do Extremo Sul Catarinense, relatando insatisfação com o seu sorriso em função da presença do freio labial maxilar. O objetivo do estudo é relatar a intervenção cirúrgica de um caso clínico com a remoção do freio labial maxilar. O freio hipertrófico, como é denominado, pode ocasionar o desnudamento do tecido cervical dos dentes, bolsas periodontais, alteração na saúde gengival, ser um fator etiológico para a presença de diastema de linha média, restrição dos movimentos dos lábios, fonação, estética, deficiên-cia de higienização devido à presença de uma camada espessa de tecido que pode interferir na harmonia dentofacial. Após o diagnóstico, o tratamento foi realizado através da técnica de Frenectomia Labial Maxilar. A frenectomia labial maxilar realizada possibilitou a prevenção do aparecimento de um futuro espaço interincisivo, sorriso harmônico e restabeleceu a autoestima da paciente que se beneficiou com o tratamento realizado. Descritores: Freio labial • Saúde bucal • Procedimentos cirúrgicos bucais AbstractThis study conducted a literature review of maxillary labial frenectomy through the search of scientific articles in several scientific databases such as MedLine, Scielo, PubMed Science Direct and reported a case of a female patient aged 17 years old without any change systemic health, who attended the school of dentistry of the Universidade do Extremo Sul Catarinense, reporting dissatisfaction with her smile due to the presence of the maxillary labial frenum. Hypertrophic frenum, can lead to the stripping of the cervical gingival tissue of teeth, periodontal pockets, change in gum health, act as an etiological factor for the presence of midline diastema, restriction of movement of the lips, speech, aesthetics, disability hygiene due to the presence of a thick layer of tissue which can interfere with dentofacial harmony. After diagnosis, treatment was performed trough labial frenectomy technique. The maxillary labial frenectomy prevented the onset of a future interincisal space, harmonic smile and restored self-esteem of the patient who benefited from the treatment performed. The aim of the study is to report the surgical intervention of a clinical case reporting the removal of the maxillary labial frenum.