Meta-Analysis of Prevalence of Xerostomia in Diabetes Mellitus

Lessa, Luiza Silveira; Pires, Patrícia Duarte Simões; Ceretta, Renan Antonio; Becker, Indianara Reynaud Toreti; Ceretta, Luciane Bisognin; Tuon, Lisiane; Simões, Priscyla Waleska Targino de Azevedo; Sônego, Fernanda Guglielmi Faustini

doi:10.3823/1823

Cited by 12 publications

(11 citation statements)

References 29 publications

(39 reference statements)

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“…This is supported by the suggestion that in general, a salivary flow rate above the threshold of 0.1–0.3 mL/min is sufficient to prevent xerostomia in most individuals (254). Still, there is sufficient literature that reports an increased prevalence of xerostomia in patients with T1DM (240, 241, 243, 255–257) and T2DM (206, 247, 248, 257, 258).…”

Section: Potential Oral Complications Of Diabetes Mellitusmentioning

confidence: 99%

Evaluating All Potential Oral Complications of Diabetes Mellitus

et al. 2019

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Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistance, dyslipidemia, hypertension, and immune dysfunction. These disturbances initiate several damaging processes, such as increased reactive oxygen species (ROS) production, inflammation, and ischemia. These processes mainly exert their damaging effect on endothelial and nerve cells, hence the susceptibility of densely vascularized and innervated sites, such as the eyes, kidneys, and nerves. Since the oral cavity is also highly vascularized and innervated, oral complications can be expected as well. The relationship between DM and oral diseases has received considerable attention in the past few decades. However, most studies only focus on periodontitis, and still approach DM from the limited perspective of elevated blood glucose levels only. In this review, we will assess other potential oral complications as well, including: dental caries, dry mouth, oral mucosal lesions, oral cancer, taste disturbances, temporomandibular disorders, burning mouth syndrome, apical periodontitis, and peri-implant diseases. Each oral complication will be briefly introduced, followed by an assessment of the literature studying epidemiological associations with DM. We will also elaborate on pathogenic mechanisms that might explain associations between DM and oral complications. To do so, we aim to expand our perspective of DM by not only considering elevated blood glucose levels, but also including literature about the other important pathogenic mechanisms, such as insulin resistance, dyslipidemia, hypertension, and immune dysfunction.

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Section: Potential Oral Complications Of Diabetes Mellitusmentioning

confidence: 99%

Evaluating All Potential Oral Complications of Diabetes Mellitus

et al. 2019

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“…Based on a recent meta-analysis study, the global prevalence of xerostomia in DM patients is 42.4%. Salivary gland defects can reduce the patient's quality of life because it causes difficulty in swallowing, speaking, chewing, dysgeusia, caries and an increase in plaque accumulation [2]. Clinically, salivary gland defects are characterized by decreased salivary secretion volume and histologically characterized by acinar cell vacuolization, which is an early sign of cell degeneration [3,4].…”

Section: Introductionmentioning

confidence: 99%

Regeneration of Salivary Gland Defects of Diabetic Wistar Rats Post Human Dental Pulp Stem Cells Intraglandular Transplantation on Acinar Cell Vacuolization and Interleukin-10 Serum Level

Narmada

Laksono

Nugraha

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To investigate the regeneration of rat's salivary gland diabetic defect after intraglandular transplantation of Human Dental Pulp Stem Cells (HDPSCs) on acinar cell vacuolization and Interleukin-10 (IL-10). Material and Methods: HDPSCs isolated from the dental pulp of first premolars #34. HDPSCs from the 3rd passage was characterized by immunocytochemistry of CD73, CD90, CD105 and CD45. Twenty-four male Wistar rats, 3month-old, 250-300 grams induced with Streptozotocin 30 mg/kg body weight to create diabetes mellitus (DM) divided into 4 groups (n=6); positive control group on Day-7; positive control group on Day-14; treatment group Day-7 (DM+5.105HDPSCs); treatment group on Day-14. On Day-7 and Day-14, rats were sacrificed. Histopathological examination performed to analyze acinar cells vacuolization while Enzyme-linked Immunoabsorbent Assay to measure IL-10 serum level. Data obtained were analyzed statistically using multiple comparisons Bonferroni test, Kruskal Wallis, Shapiro-Wilk and Levene's test result. Results: The highest acinar cell vacuolization found in control group Day 14 (0.239 ± 0.132), meanwhile the lowest acinar cell vacuolization found in treatment group Day 7 (0.019 ± 0.035) with significant difference (p=0.003). The highest IL-10 serum level found in treatment group Day 14 (175.583 ± 120.075) with significant difference (p=0.001). Conclusion: Transplantation of HDPSC was able to regenerate submandibular salivary gland defects in diabetic rats by decreasing acinar cell vacuolization and slightly increase IL-10 serum level.

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“…Research shows that polypharmacy increases the risk of developing xerostomia. 26 Similarly, knowledge increases with age and is highest among participants aged 40-59 years. Hence participants’ knowledge of their increased risk of systemic complications of diabetes is linked to their experience of disease following treatment for diabetes comorbidities and complications or ageing.…”

Section: Discussionmentioning

confidence: 99%