Peripheral nerves are excellent targets for neural interfaces designed to help amputees control prosthetic limbs. However, existing nerve interfaces have designs that significantly limit system performance. To overcome these limitations, we have combined micromachined neural interfaces with tissue-engineered hydrogel-based scaffolds. These tissue-engineered electronic nerve interfaces (TEENI) enable highly scalable nerve interfaces that provide significant interface-design freedom. The use of a hightemperature reactive-accelerated-aging (RAA) soak test sped the identification of a microfabrication processes that can yield robust nerve interfaces. Electrophysiological experiments demonstrate the high-SNR recording performance of chronically implanted TEENI devices.
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