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This review highlights the advances in the use of oxindole as starting material in the synthesis of various organic compounds and drugs. The reactions can be performed on different reactive sites of oxindole which are the carbonyl group, C-3 site, nitrogen atom, and aromatic ring. In addition, the roles of oxindole in one-pot and domino reactions are discussed.

An efficient and green condensation reaction is developed for the synthesis of (E)-arylidene-1,3-dihydroindole-2-ones; (1), using heterogeneous nanoporous acid catalyst of SBA-Pr-SO3H with pore size, 6 nm in solvent free condition. Arylidene-1,3-dihydroindole-2-ones have many pharmaceutical properties such as Tyrosin kinase inhibiton. This method has the advantages of short reaction time, isolation ease of the products, excellent yields and recyclable catalyst. Oxindole SBA-Pr-SO3H Green synthesis Solvent free reaction Tyrosin kinase inhibitor Arylidene-1,3-dihydroindole-2-ones

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