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The present work describes the catalytic activity of Cu-MOF for the one-pot synthesis of tacrine derivatives via a four-component reaction of 2-hydroxynaphthalene-1,4-dione, aldehydes, malononitrile and cycloketones in the presence of AlCl3.

Benzothiazole derivatives are essential intermediates in synthesizing a wide variety of medical and pharmaceutical compounds, and there is a great demand for a simple and efficient method to synthesize benzothiazoles under mild reaction conditions. Organic electrosynthesis as an energy-efficient process represents an environmentally benign and safer method than traditional methods for organic synthesis. Herein, we present bromine-free and straightforward synthesis of 2-amino benzothiazole derivatives via the reaction of aniline derivatives and ammonium thiocyanate using electrosynthesis in the presence of sodium bromide both as an electrolyte and as a brominating agent at room temperature in isopropyl alcohol (i-PrOH) as a solvent. The reaction of ammonium thiocyanate via C–H thiolation routes, using various aniline derivatives, resulted in a simple, green, and bromine-free synthesis of 2-amino benzothiazole in moderate to good yields under mild reaction conditions. Riluzole drug can be produced using the same procedure in moderate yields.

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Abstract. In this research, ionic liquid modi ed SBA-15 mesoporous material (SBA-IL) as a recyclable, heterogeneous catalyst e ciently catalyzed the synthesis of pyranonaphthoquinone-fused spirooxindoles through the one-pot three-component reaction of isatin derivatives, activated methylene reagents, and 2-hydroxy-1,4-naphthoquinone. The reactions were performed under microwave irradiation and solvent-free conditions. The synthesized SBA-IL was characterized by SEM, FT-IR, nitrogen adsorption-desorption, and thermogravimetric analyses. Excellent chemical yield, short reaction time, mild reaction condition, easy workup procedures, and reusability of catalyst are noteworthy advantages of this protocol.

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