An efficient and regioselective trifluoromethylation method of indole at the C2 position with ecologically-sound Langlois' reagent (CF 3 SO 2 Na) under metal-free conditions is described. K 2 S 2 O 8 in presence of glucose at room temperature has been utilized for the generation of CF 3 radicals from CF 3 SO 2 Na. The desired product can be obtained in good to excellent yields with a wide scope of substrate variability and gram scalability.
SummaryStudies of 11 patients with haemorrhagic stroke revealed no significant change in kaolin cephalin clotting time, prothrombin time, thrombin time, PF 3 availability, platelet count and factor V and VIII during the first week. Plasma fibrinogen was significantly increased while factors VII+X were decreased (borderline significance). Prolongation of plasma recalcification time and decrease in heparin tolerance reached borderline significance. There was moderate, but significant, increase in serum antithrombin activity and plasma (euglobulin fraction) fibrinolytic activity.
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