An efficient and regioselective trifluoromethylation method of indole at the C2 position with ecologically-sound Langlois' reagent (CF 3 SO 2 Na) under metal-free conditions is described. K 2 S 2 O 8 in presence of glucose at room temperature has been utilized for the generation of CF 3 radicals from CF 3 SO 2 Na. The desired product can be obtained in good to excellent yields with a wide scope of substrate variability and gram scalability.
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