Copper iodide mediated telescoped synthesis of 3-cyanoimidazo[1,2-a]pyridines, photophysical and DFT studies

K2S2O8‐Mediated C‐3 Formylation of Imidazopyridines Using Glyoxylic Acid

“…Following the inferences of control experiments (scheme 3) and prior literature reports, [5,[21][22][23][24] we tried to establish a plausible reaction mechanism of our developed methodology (Scheme 4). The reaction proceeds with the condensation of glyoxylic acid (2) to 1 a followed by its decarboxylation.…”

“…Imidazo [1,2-a]pyridine has gained significant attention among heterocycles due to its versatile reactivity and diverse biological activities. [1][2][3] Numerous therapeutically relevant compounds containing the imidazo[1,2-a]pyridine pharmacophore, such as alpidem, zolpidem, [4] necopidem, [5] GSK 812397 (anti-HIV), [6] etc. underline the importance of functionalization of this chemical entity (figure 1).…”

“…[21] Although several reports are on the formylation of indoles and small heterocyclics, there is no such report on the use of glyoxylic acid for formylation of imidazopyridines. In continuation of our interest in the functionalization of imidazo[1,2-a]pyridines [5] and persulfate-based method developments, [22,23] herein, we report a highly efficient C-3 formylation of imidazo[1,2-a]pyridines by using glyoxylic acid and persulfate.…”

Persulfate promoted regioselective C-1 thiocyanation of imidazo[1,5-a]pyridines under visible light irradiation in water

“…16 c Feng and Xu coworkers reported C-1 thiocyanation of imidazo[1,5- a ]pyridines using NH 4 SCN and synergistic cooperation of electrooxidation (platinum electrodes) and ultrasonic irradiation (50 W, 40 kHz). 16 b In continuation of our research interest in the functionalization of ImPys, 15,17 in this work, we aimed for C-1 thiocyanation of imidazo[1,5- a ]pyridines by a greener approach.…”