Tandem C–N
bond formation for the oxidative annulation of
indolines with aziridines is accomplished employing the combination
of DDQ and NaOCl at ambient conditions. Optically active aziridine
can be coupled with high enantiomeric purity (>99% ee). The substrate
scope, stereocontrol with the enantioenriched substrate, and scale-up
are the important practical advantages.
The Rh(III)-catalyzed C8-allylation of quinoline N-oxides has been accomplished using vinylcyclopropanes as an allyl source with excellent diastereoselectivity at room temperature. The C-H/C-C activation, substrate scope and natural product mutation...
The annulative coupling of donor-accetor cyclopropanes with cyclic secondary amines is reported using the combination of Ni(OTf)2 and visibile light assisted eosin Y catalysis for tandem C-N and C-C bonds...
Rh-catalyzed weak and traceless directing-group-assisted cascade C− H activation and annulation of sulfoxonium ylides with vinyl cyclopropanes as a coupling partner have been accomplished to furnish functionalized cyclopropanefused tetralones at moderate temperature. The C−C bond formation, cyclopropanation, functional group tolerance, late-stage diversifications of drug molecules, and scale-up are the important practical features.
Pd-catalyzed annulative coupling of spirovinylcyclopropyl
oxindoles
with p-quinone methides has been accomplished via cascade carbon–carbon bond formation to afford bis-spirooxindole scaffolds. The mild reaction conditions,
diastereoselectivity, functional group diversity, post-synthetic transformations,
and mechanistic studies using DFT calculations are the important practical
features.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.