“…In contrast, the functionalization of the less reactive C8–H bond, which can be accomplished utilizing quinoline N -oxide as the substrate via the formation of a five-membered metallacycle, remains synthetically challenging. , However, most of these transformations have been performed employing the rare second and third row transition metal catalysts (Rh, Ir, Pd, Ru etc. ), whereas a few studies focused on using the first row metals . In view of the synthetic modification of quinoline, C8-alkylation reactions have recently been investigated intensively due to their potential applications. ,, These alkylation reactions were realized by employing coupling partners such as activated and unactivated alkenes, alkynes, and carbenes (Scheme a) .…”