Transition-metal-aided stereoselcetive construction of sp3-carbon-rich heterocyclic scaffolds using strained ring systems have received considerable attention in recent years due to their prominent presence in myraids of natural products, bio-active molecules...

Metallaphotoredox catalysis represents the combination of two activation modes: metal-catalyzed CÀ H functionalization and visible-light-induced photocatalysis. This appealing dual catalysis technique has evolved as a versatile platform that has paved the way for diverse low-energy pathways for a plethora of synthetic transformations. The synergistic combination of two "green" approaches has garnered enormous interest owing to the development of sustainable strategies. In the recent past, significant advancements have been accomplished in constructing site-selective CÀ C and C-heteroatom bonds. This review outlines the use of photoredox catalysis in directing groupassisted CÀ H functionalization reactions. The mechanistic insights of the developments and synthetic applications are addressed.

The annulative coupling of donor-accetor cyclopropanes with cyclic secondary amines is reported using the combination of Ni(OTf)2 and visibile light assisted eosin Y catalysis for tandem C-N and C-C bonds...

Rh-catalyzed weak and traceless directing-group-assisted cascade C− H activation and annulation of sulfoxonium ylides with vinyl cyclopropanes as a coupling partner have been accomplished to furnish functionalized cyclopropanefused tetralones at moderate temperature. The C−C bond formation, cyclopropanation, functional group tolerance, late-stage diversifications of drug molecules, and scale-up are the important practical features.

Pd-catalyzed annulative coupling of spirovinylcyclopropyl oxindoles with p-quinone methides has been accomplished via cascade carbon–carbon bond formation to afford bis-spirooxindole scaffolds. The mild reaction conditions, diastereoselectivity, functional group diversity, post-synthetic transformations, and mechanistic studies using DFT calculations are the important practical features.