Transition-metal-catalyzed CÀ H functionalization is one of the fascinating scientific fronts in organic synthesis for the formation of conjugated arenes and has emerged as a benchmark to revolutionize the synthetic enterprise since past decades. In this realm, chelationguided functionalization of CÀ H bonds using an exogenous directing group has received considerable attention recently for the expedient regioselective construction of CÀ C and Cheteroatom bonds as an efficient and sustainable alternative. This article outlines our contribution towards a wide variety of transformations that have been achieved by the directed CÀ H functionalization through the fine tuning of catalytic systems.
Metallaphotoredox catalysis represents the combination of two activation modes: metal-catalyzed CÀ H functionalization and visible-light-induced photocatalysis. This appealing dual catalysis technique has evolved as a versatile platform that has paved the way for diverse low-energy pathways for a plethora of synthetic transformations. The synergistic combination of two "green" approaches has garnered enormous interest owing to the development of sustainable strategies. In the recent past, significant advancements have been accomplished in constructing site-selective CÀ C and C-heteroatom bonds. This review outlines the use of photoredox catalysis in directing groupassisted CÀ H functionalization reactions. The mechanistic insights of the developments and synthetic applications are addressed.
This article presents “state of art” trends in achieving the bidentate auxiliary assisted distal sp3 C–H functionalization beyond proximal sites. The substrate scope and mechanistic underpinnings of the key methodologies are highlighted.
Cobalt-catalyzed cascade C-N and C-O bonds formation of epoxides with hydrazones is described to furnish oxadiazines using air as the oxidant. The catalyst plays a dual role as Lewis acid...
A nickel-catalyzed C-H heteroarylation of arenes has been described using a removable oxazoline-aniline derived directing group. Utilization of inexpensive nickel(II)-catalyst, substrate scope, functional group diversity and late-stage functionalization of xanthine-derived...
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