Liver ailment is one of the severe health issues all over the sphere. Hepatic damage or failure due to consumption and breathing of hepatotoxin is increasing worldwide. Rifampicin high dosage can cause severe injury to the liver. Today publics wish herbal drugs due to its high efficiency and absence of side effects. Herbal medicines are available for each and every disorder ranging from diabetes to rejuvenators. These facts promoted us to select a medicinal plant Glinus lotoides for the present study which is known as ‘Siruserupadai’ in Tamil. Amid the later ponder, ethanolic extricate was chosen for the anti-hepatotoxicity action; it has maximum numbers of phytoconstituents (Glycosides, saponins, proteins, alkaloids, and flavanoids). Five groups of animals were taken for the test named as control, rifampicin treated group, Silymarin treated group (10 mg/Kg), Ethanolic Extract of Glinus lotoides Linn. (EEGL) treated group (200 mg/Kg), EEGL treated group 400 mg/kg. Rifampicin effectively and particularly ties to RNA polymerase; it represses the amalgamation of all shapes of RNA. It induces fatty liver and finally cirrhosis which is exited by increment the action of serum biological catalysts like SGPT, SGOT and alkaline phosphatase. The hepatoprotective activities was appeared by bringing down the serum biochemical parameters (enzymes and bilirubin) within the rifampicin inebriated rats pre-treated with ethanolic extricate at 200 and 400 mg/kg. The prophylactic impact is reasonably comparable to that of Silymarin, suggesting the EEGL can be potential source of hepatoprotectives.
Modern lifestyle, pollution, food habit, and stress have intensively enhanced the evolution of several diseases on human being. Medicinal plants are used from the ancient times for the therapeutic needs to cure various diseases as well as less toxic in nature. One of such plant is Cissus arnottiana which is used from the olden days which has been identified as an important medicine plant by many researchers all over the world. Cissus arnottiana contains phytochemicals such as alkaloids, tannins, terpenoids, flavonoids, phenolic compounds etc. In this present work methanolic stem extract of Cissus arnottiana is used to evaluate the antibacterial activity of gram negative and gram positive human pathogenic bacteria. DPPH assay is used to investigate the antioxidant properties of the methanolic extract. The anti-inflammatory activity of the extract has been studied using anti proteinase assay. The MTT cell proliferation assay is carried out against HeLa cell line in which 44% of cells are viable for the concentration of 100 µg/mL. Interestingly, the methanolic stem extract can be used as a potential candidate for new therapeutic applications.
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