Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats. Methods:To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously. The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index. Results:The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The control animals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcer index (p˂0.05). Conclusion:This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.

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Our study is intended to prepare and evaluate the polyherbal formulation (PHF) using Nyctanthes arbor-tristis, Piper nigrum, and lemon juice. Poly Herbal Formulation F1 and F2 were synthesised and subjected to qualitative, quantitative phytochemical analysis and antioxidant activity was measured using a standard protocol. Antimicrobial activity of PHFs was observed by the agar well diffusion method. The anti-inflammatory and anti-diabetic activities (In-vitro) were studied in F1 by using inhibition of albumin denaturation method. TLC and FTIR are done for the structural elucidation in F1. The F1 and F2 exhibited the presence of flavonoids, alkaloids, tannins, phenols, terpenoids, carbohydrates, saponins, Glycosides and proteins. The F1 and F2 show significant activity against the standard in the antimicrobial and antioxidant activity. The presence of flavonoids and alkaloids may contribute to the anti-microbial activity. The Nitric oxide radical scavenging activity and a metal chelating assay of the F1 possess the highest antioxidant activity of 73.1% and 69% respectively. TLC confirms the presence of flavonoids in F1. FTIR spectrum shows the functional group of amines, alcohols, nitrites, aromatic and aliphatic compounds. These FTIR bands denote stretching and vibrational bands responsible for the compounds like flavonoids, terpenoids, phenols and amino acids. This investigation shows the excellent result in antimicrobial, antioxidant and in-vitro anti-diabetic and anti-inflammatory activities. In future, the PHF of F1 can be used as potent therapeutical agents and can be further exploited for their other beneficial effect in the pharmacological studies.

Liver ailment is one of the severe health issues all over the sphere. Hepatic damage or failure due to consumption and breathing of hepatotoxin is increasing worldwide. Rifampicin high dosage can cause severe injury to the liver. Today publics wish herbal drugs due to its high efficiency and absence of side effects. Herbal medicines are available for each and every disorder ranging from diabetes to rejuvenators. These facts promoted us to select a medicinal plant Glinus lotoides for the present study which is known as ‘Siruserupadai’ in Tamil. Amid the later ponder, ethanolic extricate was chosen for the anti-hepatotoxicity action; it has maximum numbers of phytoconstituents (Glycosides, saponins, proteins, alkaloids, and flavanoids). Five groups of animals were taken for the test named as control, rifampicin treated group, Silymarin treated group (10 mg/Kg), Ethanolic Extract of Glinus lotoides Linn. (EEGL) treated group (200 mg/Kg), EEGL treated group 400 mg/kg. Rifampicin effectively and particularly ties to RNA polymerase; it represses the amalgamation of all shapes of RNA. It induces fatty liver and finally cirrhosis which is exited by increment the action of serum biological catalysts like SGPT, SGOT and alkaline phosphatase. The hepatoprotective activities was appeared by bringing down the serum biochemical parameters (enzymes and bilirubin) within the rifampicin inebriated rats pre-treated with ethanolic extricate at 200 and 400 mg/kg. The prophylactic impact is reasonably comparable to that of Silymarin, suggesting the EEGL can be potential source of hepatoprotectives.