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Clinical, radiologic, and pathologic data supported a diagnosis of osteosarcoma with multiple metastases and subcutaneous involvement.

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The authors studied the course of serum proteins during the first week and the first month of life in the calf in order to obtain useful information for neonatal care. Eight Limousine calves, four males and four females, clinically healthy, were used. From all animals blood samples were collected from the external jugular vein from the day after the birth every day for one week and every five days for thirty days. Blood samples were taken at the same hour (09:00), and the serum concentrations of albumin, globulins (α1-globulins, α2-globulins, β- globulins, γ-globulins) and total proteins were determined by means of automated multiparametric agarose gel electrophoresis system. One-way repeated measures analysis of variance (ANOVA), followed by the Bonferroni's test, was used to determine significant differences. Data analysis of variance showed a significant effect of days of life, with p < 0.05, only on albumin, α1-globulins and α2-globulins during the first month of life. These results confirm that despite the fact that newborns must adapt to various environmental factors after birth, including nutrition that can influence the serum protein profile during neonatal period, the evaluation of electrophoretic's parameters during the first months of life results useful for the diagnosis and treatment of neonatal diseases

The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 [0.24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9.23 [0.74] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactiae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.

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