Impact of Physical Exercise on Release of Cardiac Troponins: Evaluation in Healthy and Cardiopathic Dogs

Pugliese, Michela; Seminara, A.; Majo, Massimo De; Pietra, Angelo La; Niutta, P. P.

doi:10.1007/978-3-642-36488-4_24

Cited by 1 publication

(3 citation statements)

References 14 publications

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Section: Discussionmentioning

confidence: 98%

“…Our findings suggest that ExT could help veterinarians better distinguish between normal Boxers and Boxers with ACM using antemortem diagnostic tests. Our results have at least 3 practical implications: (a) developing a standardized ExT that is accessible, repeatable, and ultimately validated for use in Boxer dogs being evaluated for ACM is justified 20,21,33,38‐43,46,49 ; (b) whether a Boxer dog has exercised, or not, at the time of Holter monitoring, serum hs‐cTnI testing, or both, should be controlled as a variable that is a possible confounder; and (c) [hs‐cTnI] shows promise as part of the diagnostic armamentarium for the diagnosis of subclinical ACM in Boxer dogs and longitudinal studies should be considered.…”

Section: Discussionmentioning

confidence: 99%

“…Within 2 minutes of termination of ExT, a 12-lead ECG was obtained to document post-ExT sustained tachyarrhythmias. A venous blood sample was collected 3 hours after ExT [33][34][35] for a third [hs-cTnI] measurement (post-ExT [hs-cTnI]). Each dog then was discharged while wearing its Holter monitor.…”

Section: Methodsmentioning

confidence: 99%

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Investigation of the cardiac effects of exercise testing on apparently healthy Boxer dogs

Agarwal

Côté

O’Sullivan

et al. 2023

Veterinary Internal Medicne

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BackgroundHolter electrocardiographic monitoring is a cornerstone of diagnostic testing for arrhythmogenic cardiomyopathy (ACM) in Boxer dogs, but physical activity during monitoring is not controlled. In humans, exercise testing (ExT) can identify latent tachyarrhythmias associated with cardiomyopathy, and exercise increases serum cardiac troponin‐I concentrations ([hs‐cTnI]). These effects have not yet been investigated in Boxer dogs.Hypothesis/ObjectivesSubjecting Boxer dogs to brief, moderate‐intensity ExT can identify changes in Holter recordings and [hs‐cTnI] compared to baseline results.AnimalsThirty overtly healthy, client‐owned Boxer dogs.MethodsProspective interventional study. Dogs underwent baseline diagnostic testing including 24‐hour Holter monitoring and [hs‐cTnI], followed by brief ExT (accompanied, brisk stair‐climbing and ‐descending for <5 minutes).ResultsEleven dogs (37%) had >100 premature ventricular complexes (PVCs)/24 hours at baseline (3), ExT (3), or both (5). After ExT, these dogs had more PVCs/24 hours and greater increases in [hs‐cTnI] compared to those with ≤100 PVCs/24 hours. Dogs with the striatin mutation had more PVCs/24 hours and a greater increase in [hs‐cTnI] after ExT than did dogs without the striatin mutation.Conclusions and Clinical ImportanceExercise testing may improve the binary classification of Boxer dogs with or without ACM by increasing the number of PVCs and [hs‐cTnI] in affected dogs to a greater degree than in unaffected dogs. This effect also is associated with presence or absence of the striatin mutation. Exercise should be a controlled variable when screening Boxer dogs for ACM.

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