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Fig. 3. Fragments of tobacco mosaic virll.8, filaments of ribonucleic acid-and protein disks with a hole. x 150,000 •

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SUMMARY:The multiplication of ectromelia virus in mouse liver cells has been studied using intravenous inocula of lo6 to 1O1O LD 50 doses. About 30 yo of this virus is found in the liver in 5 min., and most of this disappears as infective virus in the next hour. After a lag period, the length of which depends on the number of LD50 doses/cell which initiated the infection, the virus titre increases again to the 5 min. level. Subsequently, steps of multiplication, each separated by a lag period, occur within each cell. The efficiency of virus multiplication over the range tested is independent of the infecting dose.