Growth Cycle of Ectromelia Virus in Mouse Liver

The Panton Memorial Lecture for 1955: The Mode of Virus Multiplication and the Susceptibility of these Agents to the Antibiotics

“…It was Hoyle, I think, who first drew attention to the fact that the growth curve of influenza A virus was step-wise and not exponential, and the same has been shown to be the case with other animal viruses such as herpes (Modi and Tobin, 1954), mouse-pox (Nossal and de Burgh, 1953) and pneumonia virus of mice (Ginsberg and Horsfall, 1951) and others. When influenza virus is introduced into the allantoic cavity of the embryonated egg it rapidly disappears from the allontoic fluid, being taken up presumably by the allantoic cells, and by the end of the first hour from 70 to 90% of the inoculum has disappeared.…”