1965
DOI: 10.1038/2081332a0
|View full text |Cite
|
Sign up to set email alerts
|

Thymus and the Production of Antibody-plaque-forming Cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
22
0

Year Published

1966
1966
2013
2013

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 61 publications
(25 citation statements)
references
References 9 publications
2
22
0
Order By: Relevance
“…Our observations on immune function clearly corroborate the reports of many investigators who have found that antibody responses to SRBC are in some way thymus-dependent [7,24,25,31,36,40,45,50,52]. Addition of neonatal irradiation to neonatal thymectomy accentuated the deficiency in response to SRBC, just as it accentuated the deficiencies in graft-versus-host reactivity and in the number of thymus-dependent cells.…”
Section: Discussionsupporting
confidence: 81%
“…Our observations on immune function clearly corroborate the reports of many investigators who have found that antibody responses to SRBC are in some way thymus-dependent [7,24,25,31,36,40,45,50,52]. Addition of neonatal irradiation to neonatal thymectomy accentuated the deficiency in response to SRBC, just as it accentuated the deficiencies in graft-versus-host reactivity and in the number of thymus-dependent cells.…”
Section: Discussionsupporting
confidence: 81%
“…Previously, Sainte-Marie, utilizing fluorescent methods, revealed the presence of antigen in the thymus gland after intravenous administration (36), and it can be demonstrated that the thymus is capable of initiating an immune response to antigen administered directly into the gland (37). Plaque-forming cells have also been recently demonstrated in the thymus after administration of sheep erythrocytes (38) and Salmonella enteridilis (24). Holub (39) has demonstrated that thymic lymphocytes are capable of immunological response, but are inhibited from doing so by the presence of thymic reticulum cells.…”
Section: Discussionmentioning
confidence: 99%
“…Transfer experiments from immunized to naive animals demonstrated that cell-mediated immunity was responsible for graft rejection and delayed type hypersensitivity. Later in the 1960s, Jacques Miller (4,5) and Henry Claman (6) and their colleagues showed that Ag-primed thymusderived lymphocytes (now called T cells) cooperated with bone marrow-derived lymphocytes (now called B cells) to enable Ab formation against sheep erythrocytes. B cells were shown to be the source of the specific Abs, but the role of Ag-specific T cells in the Ab response remained mysterious.…”
mentioning
confidence: 99%