Thymus and the Production of Antibody-plaque-forming Cells

Miller, J. F. A. P.; Burgh, P. M. De; Grant, G. A.

doi:10.1038/2081332a0

Cited by 61 publications

(25 citation statements)

References 9 publications

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“…Our observations on immune function clearly corroborate the reports of many investigators who have found that antibody responses to SRBC are in some way thymus-dependent [7,24,25,31,36,40,45,50,52]. Addition of neonatal irradiation to neonatal thymectomy accentuated the deficiency in response to SRBC, just as it accentuated the deficiencies in graft-versus-host reactivity and in the number of thymus-dependent cells.…”

Section: Discussionsupporting

confidence: 81%

The Immune Responses and Lymphoid Tissues of Neonatally Thymectomized, X-Irradiated Mice

Mosser¹,

Good²,

Cooper³

1970

Int Arch Allergy Immunol

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Section: Discussionsupporting

confidence: 81%

The Immune Responses and Lymphoid Tissues of Neonatally Thymectomized, X-Irradiated Mice

Mosser¹,

Good²,

Cooper³

1970

Int Arch Allergy Immunol

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“…Previously, Sainte-Marie, utilizing fluorescent methods, revealed the presence of antigen in the thymus gland after intravenous administration (36), and it can be demonstrated that the thymus is capable of initiating an immune response to antigen administered directly into the gland (37). Plaque-forming cells have also been recently demonstrated in the thymus after administration of sheep erythrocytes (38) and Salmonella enteridilis (24). Holub (39) has demonstrated that thymic lymphocytes are capable of immunological response, but are inhibited from doing so by the presence of thymic reticulum cells.…”

Section: Discussionmentioning

confidence: 99%

The Immune Response to Sheep Erythrocytes in the Mouse

Eidinger

Pross

1967

The Journal of Experimental Medicine

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The biological mechanisms associated with the development of the primary immune response have occupied the attention of numerous investigators. Such fundamental immunological features as the induction phase (1-3), the duration of the latent period (4-6), the cellular dynamics associated with antibody formation (5-9), the homeostatic mechanisms controlling the course of the immune response (10-12), and the development of immunological memory (13-15) have all been extensively considered.The various parameters of the primary immune response have been characterized in the past largely in terms of the appearance of various kinds of circulating antibodies. Such studies may fail to delineate some aspects of the immune response which can only be derived by analyses of the immune reaction on a cellular level. The plaque technique of Jerne and coworkers (16), which demonstrates the production of 19S immunoglobulin to sheep erythrocytes, permits such an analysis. Moreover, the recent modification by Dresser and Wortis (17) for the detection of 7S immunoglobulin production to sheep erythrocytes now allows the assessment of the immune response with respect to both types of immunoglobulins.In the present work, some of the biological features of the primary immune response were studied on a cellular level in a group of Swiss white mice. Such factors as the sequential pattern in 19S and 7S immunoglobulin production with respect to time of onset and duration of immune response were assessed after intradermal (footpad) and intravenous administration of sheep erythrocytes. Several additional features, such as the characteristics of the 19S and 7S peaks, were also considered and compared with similar manifestations in the seconddary response. Comparison was also made of the relative contributions of the proximal and distal lymphoid tissues to the total immune response of the host.

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“…Transfer experiments from immunized to naive animals demonstrated that cell-mediated immunity was responsible for graft rejection and delayed type hypersensitivity. Later in the 1960s, Jacques Miller (4,5) and Henry Claman (6) and their colleagues showed that Ag-primed thymusderived lymphocytes (now called T cells) cooperated with bone marrow-derived lymphocytes (now called B cells) to enable Ab formation against sheep erythrocytes. B cells were shown to be the source of the specific Abs, but the role of Ag-specific T cells in the Ab response remained mysterious.…”

mentioning

confidence: 99%

The Carrier Effect and T Cell/B Cell Cooperation in the Antibody Response

Parker

2013

The Journal of Immunology

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Thymus and the Production of Antibody-plaque-forming Cells

Cited by 61 publications

References 9 publications

The Immune Responses and Lymphoid Tissues of Neonatally Thymectomized, X-Irradiated Mice

The Immune Responses and Lymphoid Tissues of Neonatally Thymectomized, X-Irradiated Mice

The Immune Response to Sheep Erythrocytes in the Mouse

The Carrier Effect and T Cell/B Cell Cooperation in the Antibody Response

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