A general method for synthesis of folic acid, its conjugates and analogues.
A new and general method for the synthesis of folic acid, folic acid conjugates and folic acid analogues is described. The key step, i.e. the condensation of N(2′)‐acetyl‐6‐formyl‐pterine (I: R1 COCH3) with aminoaryl derivatives II, is achieved by refluxing in absolute ethanol to afford the azomethines III. NaBH4‐reduction followed by basic hydrolysis gives pure V products in high yield, free from 7‐isomers.
New data from 400-GeV p-nucleus interactions are analyzed to investigate the variation of normalized created-charged-particle multiplicity (R3) as a function of effective number of projectile encounters ( (v')) calculated by using the additive quark model. The data, combined with other available data from pnucleus and ?T--nucleus reactions, confirm the projectile independence of the R3-( v ' ) relationship, first observed by Kumar et al.
A phenomenological study of the rapidity-gap distribution for cosmic-ray N-h' interactions at energies 2TeV has been reported. The observations indicate strong short-short correlations in rapidity gaps which support Snider's two-channel multiperipheral cluster model. The cluster size and cluster density at these energies have been estimated to be 6.5 and 1.0, respectively. It is found that with increasing energy, the cluster size practically remains constant but the number of clusters produced per collision rises slowly.
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