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Twenty-three individuals with multiple sclerosis (MS) participated in a 6-month exercise training program; 11 ambulatory (AMB) and 8 semi-ambulatory (SEMI). Four persons with MS served as non-exercising controls (C). A test of maximal aerobic power (VO 2max ) was administered at baseline to all subjects. AMB and SEMI subjects exercised on alternating days for 30 minutes, at 55-60% VO 2max using either a commercially available recumbent or upright combination leg/arm bicycle ergometer. At the end of 12 and 24 weeks, exercising subjects were reevaluated. The C group was only re-evaluated at 24 weeks. The results show that the AMB and SEMI groups experienced a +20% and +5% improvement in VO 2max , respectively. The C group averaged a 12% decline in VO 2max during the 6 months. These data demonstrate the possibility that although exercise improves cardiovascular fitness of some persons with less severe MS, this beneficial response may not apply to the more severely impaired patient. Nevertheless, improved cardiovascular health at any level may enhance the overall rehabilitation outcome of many individuals in this patient population.

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