Change in aerobic fitness of patients with multiple sclerosis during a 6‐month training program

Ponichtera-Mulcare, J. A.; Mathews, Thomas; Barrett, P. J.; Gupta, Shikhar

doi:10.1080/15438629709512089

Cited by 52 publications

(35 citation statements)

References 5 publications

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“…Doing so may help manage the many disabling symptoms often associated with the disease including muscle weakness 2 , reduced balance 3,4 , reduced mobility 3 , reduced exercise tolerance 5,6 and fatigue 7 . Cumulative evidence suggests that exercise may help improve some of these symptoms [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study

et al. 2011

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Objective: To establish the effects of a twelve week, community based, group exercise intervention for people moderately affected with Multiple Sclerosis (MS) (Extended Disability Status Score 5-6.5). Design: Randomised controlled pilot trialSetting: Two community leisure centres.Participants: 32 subjects with MS were randomised into an intervention or control group. Intervention:The intervention group received twelve weeks of twice weekly, 60 minute group exercise sessions, which included mobility, balance and resistance exercises. The control group received usual care. Main Outcome measures:An assessor blinded to group allocation assessed participants at baseline, after eight weeks and after twelve weeks (i.e after the intervention period). The primary outcome measure was 25 Foot Walk time (T25FW), secondary outcomes assessed walking endurance, balance, physical function, leg strength, body mass index, activity levels, fatigue, anxiety and depression, quality of life and goal attainment. ResultsThe intervention led to an improvement in all outcome measures. Physical activity results showed a significant group effect (p<0.001) and interaction effect (p=0.009), post hoc analysis revealed this was significant at week eight (p<0.001) and week twelve (p=0.005).Balance confidence results showed a significant group effect (p=0.001). Good effect sizes were found for activity levels (d=1.05), dynamic balance (d=0.80), perceived balance (d=0.94) and leg strength (d=1.33). Conclusion:Although further research is required, the results of the study suggest that community based group exercise classes are a feasible option for people moderately affected with MS, and offer benefits such as improved physical activity levels, balance and leg strength.3

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Section: Introductionmentioning

confidence: 99%

The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study

et al. 2011

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“…DeBolt and McCubbin found that 8 weeks of home-based resistance exercise training increased leg power [11]. Aerobic exercise, which has been reported to increase the isokinetic peak torque of the knee extensor [12], increased both the distance covered in a 6-minute walking test [13] and maximal oxygen consumption [14][15][16]. However, this type of training requires active patient participation.…”

Section: Introductionmentioning

confidence: 99%

Decreased central fatigue in multiple sclerosis patients after 8 weeks of surface functional electrical stimulation

Chang¹,

Hsu²,

Chen³

et al. 2011

JRRD

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Abstract-Effective treatments for multiple sclerosis (MS)-associated central fatigue have not been established. Surface functional electrical stimulation (FES), which can challenge the peripheral neuromuscular system without overloading the central nervous system, is a relatively safe therapeutic strategy. We investigated the effect of 8 weeks of surface FES training on the levels of general, central, and peripheral fatigue in MS patients. Seven of nine individuals with MS (average age: 42.86 +/-13.47 years) completed 8 weeks of quadriceps muscle surface FES training. Maximal voluntary contraction, voluntary activation level, twitch force, General Fatigue Index (FI), Central Fatigue Index (CFI), Peripheral Fatigue Index, and Modified Fatigue Impact Scale (MFIS) scores were determined before and after training. The results showed that FI (p = 0.01), CFI (p = 0.02), and MFIS (p = 0.02) scores improved significantly after training. Improvements in central fatigue contributed significantly to improvements in general fatigue (p < 0.01). The results of the current study showed that central fatigue was a primary limitation in patients with MS during voluntary exercise and that 8 weeks of surface FES training for individuals with MS led to significantly reduced fatigue, particularly central fatigue.

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“…Although exercise programs for people with MS can increase fitness levels [2][3][4], whether these programs actually increase the amount of daily physical activity performed is not clear. This omission may be a result of the difficulties inherent in measuring physical activity in the free-living situation.…”

Section: Introductionmentioning

confidence: 99%

Reliability of RT3 accelerometer for measuring mobility in people with multiple sclerosis: Pilot study

Hale

Williams²,

Ashton³

et al. 2007

JRRD

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Abstract-This pilot study investigated the test-retest reliability of an RT3 accelerometer (RT3) for measuring motion in people with multiple sclerosis (MS). Ten people with MS (mean age 49 yr; Extended Disability Status Scale mean +/-standard deviation = 3.4 +/-1.3) and ten nondisabled people (mean age 40 yr) wore the RT3 while they performed three discrete mobility tasks on two occasions separated by 1 week. The intraclass correlation coefficients (ICCs) calculated from the RT3 motion data for the group with MS were 0.64 for the 5-minute walk test (p = 0.01), 0.50 for the timed up and go test (p = 0.05), and 0.76 for the stair-climbing task (p = 0.002). For the control group, these values were 0.65 (p = 0.01), -0.04 (p = 0.54), and 0.39 (p = 0.11), respectively. We found that the RT3 can potentially provide stable data when measuring walking, but a more robust, yet participant-friendly, method of attaching the RT3 is required. Both participant groups demonstrated inconsistencies in motor-task performance, highlighting a potential source of measurement error that would need to be addressed when future studies are designed. Based on the results of the 5-minute walk test in this study, a sample of 53 participants would be required to obtain an ICC value with a 95% confidence interval of width 0.2 using two repeat measurements.

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Change in aerobic fitness of patients with multiple sclerosis during a 6‐month training program

Cited by 52 publications

References 5 publications

The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study

The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study

Decreased central fatigue in multiple sclerosis patients after 8 weeks of surface functional electrical stimulation

Reliability of RT3 accelerometer for measuring mobility in people with multiple sclerosis: Pilot study

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