The urinary excretion of total androstenedione i. e. free, glucosiduronide and sulphate, testosterone and dehydroepiandrosterone during two normal menstrual cycle is presented. Epitestosterone was determinated during one cycle only. Both cycles were ovulatory as can be seen from the pregnanediol and oestriol determinations.
The androstenedione and testosterone excretion values showed a caracteristic decrease from 12th to 16th day and an increase during the luteal phases, reaching their maximal levels between the 20th and 25th (cycle A) and 20th and 24th day (cycle B) respectively. The excretion values of epitestosterone were highest on 22nd and 23rd day. Dehydroepiandrosterone values were also slightly raised during the luteal phase of the cycle.
Summary
Precocious puberty with signs of masculinization and elevation of choriogonadotrophic activity in a girl 7½ years old was found to be due to a hormonally active ovarian tumour. The tumour was composed of germ cells, Leydig cells, Sertoli granulosa‐like cells, trophoblastic and teratoid portions, and was therefore, termed a terato‐chorio‐gonadoblastoma. Hormonal data were correlated with the histological and ultrastructural findings. This unusual tumour caused precocious puberty coupled with virilization and high choriogonadotrophic activity in a girl 7½ years old.
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