Precocious Puberty With Masculinization Due to Terato‐chorio‐gonadoblastoma

Drobnjak, P; Damjanov, Ivan; Grizelj, V.; Kalafatić, Z; Longhino, N

doi:10.1111/j.1471-0528.1971.tb00351.x

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…The clinical presentation is typical of a patient with a rapidly enlarging ovarian tumor, namely abdominal pain and swelling, but a few of our patients presented with endocrine manifestations including precocious puberty and androgenic signs. Sporadic patients in the literature have had one or sometimes even both endocrine findings, precocious puberty being most common 38–42. This was almost invariably seen in patients whose tumor had syncytiotrophoblastic giant cells, as a component of choriocarcinoma but more often within embryonal carcinoma or dysgerminoma 43.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mixed Germ Cell Tumors of the Ovary

Safdar

Stall

Young

2020

American Journal of Surgical Pathology

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One hundred malignant mixed germ cell tumors of the ovary that occurred in patients 3 to 55 years (mean: 20 y) of age are described. The clinical presentation was usually that of any highly malignant tumor of the ovary (abdominal pain and distension), but rarely (3 cases) endocrine manifestations were present. The tumors were usually unilateral (96%), ranged from 4 to 38 cm (mean: 16 cm), and were uniformly solid or, more often, solid and cystic; occasionally the typical appearance of dysgerminoma could be appreciated. The most common tumor type was yolk sac tumor (91%), followed by dysgerminoma (61%), immature teratoma (58%), embryonal carcinoma (38%), and choriocarcinoma (11%). A variety of admixtures were encountered; dysgerminoma and yolk sac tumor was the most common combination (25% of the tumors) with the 2 components often being sharply demarcated. Immature teratoma and yolk sac tumor was the next most common pairing (20%) followed by yolk sac tumor and embryonal carcinoma, with or without immature teratoma (16%). Tumors with a choriocarcinoma component had the most varied combinations of tumor types. Embryoid bodies were seen in 21% of the tumors, most often as fragmented forms arranged in a nodular manner with yolk sac tumor and/or embryonal carcinoma; uncommonly they occurred singly or in clusters. Numerous confluent well-formed embryoid bodies (polyembryoma) were prominent in 2 tumors. Three tumors had a focal diffuse embryoma pattern. The specific tumor types showed the known diverse spectrum of microscopic appearances, but the frequent haphazard arrangement of 2 or more subtypes often resulted in complex morphology. Overgrowth of another neoplastic component, most often primitive neuroectodermal tumor, occurred in 10% of the tumors further complicating the histologic picture. This is the largest series of ovarian malignant mixed germ cell tumors reported and details their characteristics including associations of their subtypes and the frequent apparent role of embryoid bodies in giving rise to yolk sac tumor and embryonal carcinoma components.

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Section: Discussionmentioning

confidence: 99%

Malignant Mixed Germ Cell Tumors of the Ovary

Safdar

Stall

Young

2020

American Journal of Surgical Pathology

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“…solid teratoma and sometimes with dysgerminoma (Teter and Boczkowski, 1967;Schellhas et al, 1971;Drobnjak et al, 1971;Gallagher and Lewis, 1973). Malignant teratoma has been described by Frasier et al (1964) and by Scully (1970).…”

Section: Associated Tumoursmentioning

confidence: 99%