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Quantitative analysis of the EEG (q-EEG) in patients with obsessive compulsive disorder (OCD) showed a decreased beta and an increased theta power at frontotemporal regions. The patients who had higher scores in doubting test (Maudsley Obsessive Compulsive Questionnaire) and more severely ill patients shared similar q-EEG features. The relative theta powers were significantly increased and alpha powers were significantly decreased in these patients, particularly in the frontotemporal region. It was suggested that the q-EEG may be useful in investigating the OCD patients with heterogeneous characteristics.

ÖZET Amaç: Bu çalışmada DSM-5 Bozuklukları için Yapılandırılmış Klinik Görüşme-Klinisyen Versiyonunun (SCID-5/CV) Türkçeye uyarlanması ve güvenilirliği araştırılmıştır.Yöntem: Araştırma iki üniversite hastanesinde ayaktan ya da yatarak tedavi alan 185 hastayla yürütülmüştür. SCID-5/ CV(KlinisyenVersiyonu)'nin özellikleri ve kullanımı konusunda eğitim toplantıları yapılması sonrasında, bir psikiyatrist görüşmeci iken diğeri gözlemci; diğer psikiyatrist görüşmeci iken diğeri gözlemci olacak şekilde uygulanmıştır. Görüşmeciler arası güvenilirlik araştırılmış ve Cohen kappa katsayısı hesaplanarak istatistiksel değerlendirme yapılmıştır. Bulgular:Hastaların yaş ortalaması 37,2±13,5'ti ve %55,7'si kadındı, %38,9'unun eğitim durumu yükseköğretim, %23,8'inin lise, %33'ünün ilköğretim, %1,6'sı okuryazar ve %2,7'si okuryazar değildi. Kappa katsayısının, şizofreni (κ=0,93), bipolar bozukluk (κ=0,96), major depresif bozukluk (κ=0,89), distimik bozukluk (κ=0,82), alkol kullanım bozukluğu (κ=0,96), panik bozukluğu (κ=0,84), agorafobi (κ=0,85), toplumsal kaygı bozukluğu (κ=0,95), yaygın anksiyete bozukluğu (κ=0,89), obsesif kompulsif bozukluk (κ=0,87), travma sonrası stres bozukluğu (κ=0,89), erişkin dikkat eksikliği ve hiperaktivite bozukluğu (κ=1,00), özgül fobi (κ=0,82) için mükemmel uyumu yansıttığı bulunmuş; bedensel belirti bozukluğu (κ=0,65) ve uyum bozukluğu (κ=0,78) için çok iyi uyumu yansıttığı bulunmuştur.Sonuç: Geçmiş SCID versiyonlarına benzer şekilde kappa katsayısı oldukça yüksek bulunmuştur ve hepsi istatistiksel olarak anlamlıdır. SCID-5/CV'nin Türkçe versiyonu hem günlük klinik pratikte hem de klinik çalışmalarda güvenilir bir şekilde kullanılabilir.Objective: In this study, we aimed to adapt the Structured Clinical Interview for DSM-5-ClinicianVersion into Turkish and to demonstrate its reliability. Method:A total of 185 patients, both inpatient and outpatient, from two different university hospitals were included. Training sessions on the features and use of SCID-5/CV were held before the data collection. During the study, in order to test the diagnostic agreement and accuracy, two psychiatrists remained present at the evaluation of each participant; alternatively being interviewer and the observer. Cohen's kappa coefficient for inter-rater reliability was calculated for every diagnostic category. Results:The patient group had a mean age of 37.2 (±13.5) years and 55.7% were female. The education status was as follows: 2.7% were illiterate, 1.7% literate with no primary education, 33% had primary education, 23.8% had secondary education and 38.9% had higher education. The calculated kappa value showed excellent agreement for schizophrenia (κ=0.93), bipolar disorder (κ=0.96), major depressive disorder (κ=0.89), dysthymic disorder (κ=0.82), alcohol use disorder (κ=0.96), panic disorder (κ=0.84), agoraphobia (κ=0.85), social anxiety disorder (κ=0.95), generalized anxiety disorder (κ=0.89), obsessive compulsive disorder (κ=0.87), posttraumatic stress disorder (κ=0.89), adult attention deficit and hyperactivity di...

A significant proportion of cancer patients experience psychiatric morbidity. Potential predictors of psychiatric morbidity include patient disease-related factors and factors relating to the patient's environment. The aim of this study was to investigate the prevalence of psychiatric morbidity and the relationship between the clinical or personal factors, especially psychiatric morbidity, and awareness of cancer diagnosis among a group of Turkish cancer patients. A total of 117 cancer patients were assessed using the Structured Clinical Interview for DSM-IV (SCID), the Hospital and Anxiety Depression Scale (HADS) and the General Health Questionnaire (GHQ). Of these patients, 30% had a psychiatric diagnosis. Adjustment disorders comprised most of the psychiatric diagnoses. Awareness of the diagnosis of cancer, history of previous psychiatric disorders, pain and stress factors were correlated with psychiatric morbidity. Of the 117 patients, 64 (54.7%) were unaware of the diagnosis of cancer. Most of the patients (67.9%) who were considered to be aware of the cancer diagnosis stated that they had guessed their illness from the treatment process or drug adverse effects. Psychiatric morbidity was significantly higher in the patients who knew that they had a cancer diagnosis (P=0.03). These findings suggest that the awareness of cancer diagnosis is related to the presence of psychiatric morbidity. In particular, the understanding of the diagnosis indirectly may be stressful to the patient because it arouses suspicion about the cancer and treatment, and consequently can lead to psychiatric disturbance. In Turkey honest disclosure of the true diagnosis is still not common for cancer patients and it seems to be essential to improve this situation.

This study aimed to investigate the clinical features of obsessive-compulsive disorder (OCD) and the possible association between obsessive-compulsive symptoms and culture-related characteristics in a sample of Turkish patients with OCD. We studied 141 patients with OCD (according to DSM-IV criteria) consecutively admitted to our outpatient clinic during the period from February 1998 to December 2003. We used the Turkish version of the Structured Clinical Interview for DSM-IV (SCID) to interview all patients, and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to assess obsessive-compulsive symptoms and severity. The onset of OCD symptoms was earlier in males. Major depression was the most common comorbid disorder (30.5%). The most commonly occurring obsessions were contamination (56.7%), aggression (48.9%), and somatic (24.1%), followed by religious (19.9%), symmetry (18.4%), and sexual imagery (15.6%). Symmetry and sexual obsessions, and checking compulsions and rituals, tended to be more common in male patients. Dirt and contamination obsessions and washing compulsions were slightly more common in females. The vast majority of patients with religious obsessions (83%) and half of the patients with sexual obsessions had compulsions that included religious practices. Also, patients with sexual and religious obsessions had delayed seeking professional help.

Reelin is an extracellular matrix-associated protein important in the regulation of neuronal migration during cerebral cortical development. Point mutations in the RELN gene have been shown to cause an autosomal recessive human brain malformation termed lissencephaly with cerebellar hypoplasia (LCH). Recent work has raised the possibility that reelin may also play a pathogenic role in other neuropsychiatric disorders. We sought, therefore, to define more precisely the phenotype of RELN gene disruption. To do this, we performed a clinical, radiological, and molecular study of a family in whom multiple individuals carry a chromosomal inversion that disrupts the RELN locus. A 6-year-old girl homozygous for the pericentric inversion 46,XX,inv7(p11.2q22) demonstrated the same clinical features that have been previously described in association with RELN point mutations. The girl's brain magnetic resonance imaging (MRI) findings, including pachygyria and severe cerebellar hypoplasia, were identical to those seen with RELN point mutations. Fluorescence in situ hybridization confirmed that one of the breakpoints of this inversion mapped to within the RELN gene, and Western blotting revealed an absence of detectable serum reelin protein. Several relatives who were heterozygous for this inversion were neurologically normal and had no signs of psychotic illness. Our findings demonstrate the distinctive phenotype of LCH, which is easily distinguishable from other forms of lissencephaly. Although RELN appears to be critical for normal cerebral and cerebellar development, its role, if any, in the pathogenesis of psychiatric disorders remains unclear.

In the present study, the findings are useful in showing the risk factors related to suicidal behavior.

Mrs P, a 46-year-old married woman with a 9-year history of recurrent depressive illness, presented with depressed mood, 194