Quantitative Eeg Analysis in Obsessive Compulsive Disorder

Karadag, Filiz; Oğuzhanoğlu, Nalan Kalkan; Kurt, Tülay; Oğuzhanoğlu, Attila; Ateşçi, Figen Çulha; Özdel, Osman

doi:10.1080/00207450390200963

Cited by 62 publications

(62 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased theta in OCD is a robust finding (Karadag et al, 2003;Perros, Young, Ritson, Price & Mann, 1992;Velikova et al, 2010) and the regions of activation are consistent with OCD imaging studies (Rotge et al, 2008), suggesting the activation of OCD-related circuitry. However, a more parsimonious explanation may be that this reflects greater anxiety (Aftanas & Pavlov, 2005) or more vivid imagery (Addis, Wong & Schacter et al, 2007;Weiler, Suchan & Daum, 2010).…”

Section: Discussionsupporting

confidence: 67%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

View full text Add to dashboard Cite

Background and aims:The behavioural addiction model of obsessive-compulsive disorder (OCD) proposes that as compulsions successfully reduce obsession-provoked anxiety in the early stages of the disorder, their performance is rewarding and therefore potentially addictive. According to this theory, the urge to perform a compulsion or neutralization resembles craving in addiction, and ventral fronto-striatal reward circuitry is activated during compulsive or neutralizing behaviour, resembling substance addiction disorders. The current study used EEG source localisation to test this hypothesis by examining brain activity accompanying the urge to neutralize and covert neutralization. Methods: Two groups of non-clinical participants (15 Low-OC, 15 High-OC) performed a task in which the urge to neutralize was induced by supplying participants with an obsessive-compulsive-like thought. Source localised EEG activity was compared between a negative condition with high urge to neutralize, and a positive condition with low urge to neutralize, and correlations between brain activity and self-reported urge to neutralize were examined. Results: High-OC participants reported a significantly greater urge to neutralize than Low-OC participants, and the majority of participants reported performing covert neutralization during the experiment. Between-condition comparisons in the High-OC group revealed significantly greater alpha activity in the insula and vlPFC in the negative than the positive condition, which was significantly correlated with both urge to neutralize and later decrease in negative affect. Conclusions: The current results support the proposal that the urge to neutralize in OCD is neurally similar to craving in substance addiction, in agreement with the behavioural addiction model of OCD.

show abstract

Section: Discussionsupporting

confidence: 67%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

View full text Add to dashboard Cite

show abstract

“…The data add to the findings of other groups, who as well revealed influences of demographic or clinical characteristics, such as sex, character and severity of the symptoms, or confounding effects of depression, on neurophysiological variables (Tot et al, 2002;Karadag et al, 2003). QEEG, although of limited diagnostic use in psychiatry, should be considered as a tool to investigate the pathophysiological background of psychiatric disorders.…”

Section: Discussionmentioning

confidence: 90%

“…Early EEG studies in patients with OCD, simply based on visual inspection, have reported a higher rate of abnormal patterns with unspecific slow wave abnormalities (Pacella et al, 1944) and a diffuse nonspecific theta-activity (Insel et al, 1983). Although most of the more recent quantitative EEG studies revealed abnormalities predominantly in frontal and frontotemporal regions (Jenike and Brotman, 1984;Prichep et al, 1993;Kuskowski et al, 1993;Locatelli et al, 1996;Karadag et al, 2003), the reported changes were not homogeneous and were partly conflicting. The observations comprised reductions in absolute delta and beta power with a corresponding increase in relative alpha International Journal of Psychophysiology 62 (2006) 87 -92 www.elsevier.com/locate/ijpsycho power (Kuskowski et al, 1993), or an increase in relative deltabut a decrease in relative alpha -power (Locatelli et al, 1996).…”

Section: Introductionmentioning

confidence: 87%

Symptom-specific EEG power correlations in patients with obsessive–compulsive disorder

Pogarell

Juckel

Mavrogiorgou

et al. 2006

International Journal of Psychophysiology

View full text Add to dashboard Cite

“…An increase in alpha and beta waves (Velikova et al, 2010;Bolwig, Hansen, Hansen, Merkin, & Prichep, 2007), decrease in alpha and beta waves (Bucci et al, 2004;Serra, Palma, Nolfe, & Buscaino, 1994) and delta or theta waves increase (Koprivova et al, 2011;Velikova et al, 2010;Pogarell et al, 2006;Karadag et al, 2003;Tot, Ozge, Comelekoglu, Yazici, & Bal, 2002;Simpson, Tenke, Towey, Liebowitz, & Bruder, 2000) were reported in OCD patients. For instance, the results of Bucci et al, (2004) suggests a relative decrease of alpha band activity among OCD patients before treatment, which was then normalized following the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the results of Bucci et al, (2004) suggests a relative decrease of alpha band activity among OCD patients before treatment, which was then normalized following the treatment. Patients with OCD have shown an increase in the theta band at frontotemporal regions (Karadag et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Psychoneurotherapy on Reducing Symptoms Severity in Treatment Naïve Patients With Obsessive-Compulsive Washing

Saremi

Nazari

Shariat

et al. 2016

PCP

View full text Add to dashboard Cite

Objective: The present study was carried out to examine the effectiveness of psychoneurotherapy (PNT) on reducing symptoms severity in treatment-naïve patients with obsessive-compulsive washing. This study evaluated a new form of psychotherapy based on neurobiological model of Obsessive-Compulsive Disorder Washing (OCD-W). Methods:The study was conducted as a quasi-experimental research. The statistical population of this study included 130 obsessive-compulsive washers. A total of 40 patients were selected using convenience sampling method and then were randomly divided into two groups: PNT group (n=20) and sham feedback control group (n=20). Both groups received drug treatment, in addition, the experimental group received 20 sessions (twice per week) of PNT. The Yale-Brown obsessive compulsive scale (Y-BOCS), Maudsley obsessional-compulsive inventory (MOCI), depression, anxiety, and stress scale-21 (DASS-21), subjective united distress scale (SUDS) were administered before and after treatment. Eelectroencephography (EEG) was recorded in eyes open provocation stimuli condition. All EEGs were recorded drug free. Participants were prescribed PNT protocol based on the results of their quantitative EEG (QEEG) and low-resolution electromagnetic tomography analyses. The effects of PNT were analyzed using 1-way analysis of covariance (ANCOVA) after controlling pretest scores. The effect size (Cohen's d), paired t test, and clinically significant change were calculated and assessed for all the clinical instruments.Results: Thirty patients completed this study. Despite some methodological limitations, our results indicated that psychoneurotherapy is significantly efficient on treatment's target. ANCOVA results supported that PNT could significantly improve the severity of OCD symptoms, depression, stress, anxiety symptoms, and subjective united distress scale compared to what was seen sham feedback control group (All P<0.001). Conclusion:Psychoneurotherapy showed preliminarily evidence for the effectiveness in the treatment of patients with obsessive-compulsive washing. The study is an attempt to provide a new non-invasive treatment of OCD-washing. Further studies are necessary for confirming our findings.

show abstract

Quantitative Eeg Analysis in Obsessive Compulsive Disorder

Cited by 62 publications

References 37 publications

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Symptom-specific EEG power correlations in patients with obsessive–compulsive disorder

The Efficacy of Psychoneurotherapy on Reducing Symptoms Severity in Treatment Naïve Patients With Obsessive-Compulsive Washing

Contact Info

Product

Resources

About