Introduction:The platelet-rich plasma (PRP) is part of a set of biotechnologies, providing some growth factors that promote repair of different tissues. The polypropylene meshes (PPM) are applied in the correction of abdominal defects, pelvic floor and urinary incontinence, however, they induce many significant complications, as a result of an inappropriate inflammatory response.Purpose:To investigate the changes caused by PRP associated with the implantation of PPM in the abdomen of female rabbits, in the production of collagen I and III and the inflammatory infiltrate (ININ).Materials and Methods:We performed implant meshes with and without PRP in adult rabbits (n=30) and euthanasia at 7, 30 and 90 days. Two plates were prepared from each animal and analyzed in five different fields. The ININ was evaluated by quantification of inflammatory cells using hematoxylin-eosin and the collagen by Sirius red method. The results were analyzed applying the Wilcoxon, Kruskal-Wallis, Junckheere and Friedmann tests.Results:There was a significant difference in the number of inflammatory cells between the groups with and without PRP (p=0.01) at 90 days. There was increased production of collagen I, III and total with the use of PRP, at seven days.Conclusion:The PPM coating with PRP was associated with increased ININ at the implant area, and an increasing trend during the process of tissue repair. The PPM coated with PRP was related to increased concentration of collagen I, collagen III and the concentration of total collagen increased after seven days of implantation.
Among male patients, bladder cancer is the fourth most common and is rarely identified in young individuals. The most common symptom is macroscopic hematuria and the initial treatment is transurethral resection of the bladder, in which the stage and classification are identified. Smoking is known to be the main risk factor for bladder cancers. Radical cystectomy and bilateral pelvic lymphadenectomy are the “gold standard” treatment for muscle-invasive bladder cancer. Around 25% of bladder neoplasms are muscle-invasive at diagnosis, but the patients have a good prognosis with this kind of treatment. The Bricker technique is the most used for the reconstruction of the neobladder. In this paper we report the case of a male patient, 55 years old, with invasive high-grade bladder cancer, treated with a radical cystectomy, lymphadenectomy and neobladder using the Bricker technique. After the surgical procedure, the patient remained in the Intensive Care Unit for two days, presenting acute kidney injury and the need for three hemodialysis sessions. The recovery was adequate, with a good postoperative evolution. We emphasize the importance of reporting to the patient about the indispensable clinical follow-up, which must be done until medical discharge, to avoid disease recurrence and the need for more aggressive treatments, as we will see in this case.
40% das pacientes com diabetes tipo 2. A obesidade abdominal, idade e tipos de parto mostraram-se ser importantes fatores de risco para o desenvolvimento da IU, implicando na elaboração de intervenções nos vários níveis de atenção à saúde no tratamento da IU.
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