Heat shock protein 27 (HSP27) belongs to a family of ATP-independent chaperones and plays a fundamental role in cell physiology in various disease states, including cancer. So, it was found that serum HSP27 levels were significantly increased in patients with various tumors, but their significance in laryngeal carcinoma is not well defined. Purpose of the study. Determination and comparison HSP27 serum levels at different stages of special treatment methods in laryngeal cancer patients. Materials and methods. The studies were conducted in 31 patients of laryngeal cancer of T2–3 N0 M0 categories before treatment and at its various stages. The serum HSP27 levels analysis was carried out using the «ELISA» diagnostics test system by enzyme immunoassay. Results. The serum HSP27 levels in patients before treatment and with various types of special treatment are statistically significantly higher than the control values. There was a decrease in serum HSP27 levels in patients after removal of the neoplasm and a slight increase in serum HSP27 levels after completion of radiation therapy. Comparison of initial serum HSP27 values in patients with subsequent relapse of the disease with initial serum HSP27 levels in patients with positive treatment outcomes did not reveal statistically significant differences. Conclusion. The serum HSP27 levels in laryngeal cancer patients are elevated and remain so at all treatment stages. Initial level of serum HSP27 cannot predict tumor recurrence. Keywords: laryngeal cancer, HSP27.
Thiol groups of the intra and extracellular molecules are antioxidant and protect cells from damage caused by free radicals, but dynamics data of serum total thiol (sTT) levels in patients at laryngeal cancer are almost absent. Purpose of the study: Determination and comparison the serum total thiol levels at different stages of special treatment methods in laryngeal cancer patients. Material and methods: In twenty-eight laryngeal cancer (T2-3 NX M0 category) patients’ examination of the thiol status dynamics was carried out before, during and after the combined treatment with “ELISA” diagnostics test system. Results: Almost a twofold decrease in sTT content indicators was noted but no identified statistically significant differences between T2 and T3 categories tumors. There was an increase in sTT levels in patients in the postoperative and during radiation therapy period, which, however, were below the control values. At the same time, when the combined treatment was completed, a significant decrease in the level of sTT was noted, which emphasizes the need for long-term antioxidant therapy. Higher sTT levels have been associated with a reduced risk of laryngeal cancer recurrence. Conclusions: In laryngeal cancer patients, the level of serum total thiol was lower than in patients of the control group. There were no statistically significant differences in sTT levels in patients with T2 and T3 tumors. Low levels of the serum total thiol are related with predict a poor outcome for patients.
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