Single crystals of new non-centrosymmetric iodate Ba(IO3)OH are synthesized hydrothermally and structurally investigated. OD topology-symmetry analysis of layers and their alternation led to conclusions about the similarity with the Bi(IO3)O nonlinear-optical crystal. Both structures are members of a general family with differences in structures and properties. AgBi(IO3)4 and AgBi(SO4)(IO3)2 belong to another family with the two types of layers giving different local symmetry. The properties are estimated semi-quantitatively based on structural data. Such an approach is new and promising. Hypothetical structural variants are predicted.

Background and aim: The metabolic syndrome (MetS) has become one of the most important clinical issues in the cardiovascular field for this decade because of the marked increase in cardiovascular (CV) risk associated with a clustering of risk factors. The aim of the current study was to evaluate the relationship between MetS and its components and cardiovascular disease (CVD). Methods: This population-based cross-sectional study was based on data from two studies carried out in Russia (ESSE-RF) and Italy (PLIC). One sample from each cohort was selected, matching individuals by sex and age. A comparison between samples of MetS components distribution and CV risk, according to SCORE chart, has been conducted. Results: A total of 609 individuals (mean [SD] age 55 [8] years, about 39% males) for each cohort were selected. Almost half of PLIC cohort participants belonged to the moderate CV risk group (47% vs 27%), while in ESSE-RF cohort a relatively higher prevalence of individuals classified in the high and very high risk group was observed (19% vs 11%, 21% vs 6%, respectively). Overall, 43% of ESSE-RF participants were diagnosed with MetS, compared with the 27% of PLIC members (the difference in prevalence becomes 37% vs 21%, considering a more conservative cut-off for waist circumference). Both cohorts showed a trend towards the increase of MetS components moving from the lowest to the highest CV risk class, with a high prevalence of patients with four or five MetS determinants allocated in the high/very high CV risk group. Conclusions: Developing effective public health strategies for the prevention, detection and treatment of MetS should be an urgent priority to reduce the burden of CVD, not only in subjects at high/very high CV risk, but also in those characterized by a lower risk, as even rare CV events that come from low risk group bring a tangible burden to healthcare systems.

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Two polytypic modifications of new non-centrosymmetric iodate Rb3Sc(IO3)6 are synthesized hydrothermally. Their structures demonstrate different degrees of ordering and are solved in the same space group, Pc, with differing choice of b-axis: either 20 or 40 Å is selected from the same diffraction data, measured on crystals with better ordering. The difference in NLO properties of two polytypes is disclosed. Topology–symmetry analysis of separated blocks and layers allowed determination of local symmetry corresponding to mirror plane m, which defines strong optical nonlinearity. Layer alternation indicates a polytypic nature of Rb, Sc-iodate and its similarity to K, In- and K, Sc-nonlinear-optical iodate crystals, space group Fdd2, belonging to the proposed common family A3M(IO3)6 (A = K, Rb; M = Sc, In), whose properties are explained on a symmetry basis for every known member. Hypothetical structural variant is predicted; structural disorder and crystal growth conditions are discussed as factors affecting properties.

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Despite the advances in lipidology over the past decade, the control of dyslipidemia at the population level in Russia, as in a number of European countries, remains unsatisfactory. The need for novel organizational approaches to solving the problem at the regional and federal levels is obvious. This publication provides an overview of the implemented projects and the successful practical experience of lipid centers in Russia, as well as the prospects for the development of novel models that will optimize the care provision for patients with lipid metabolism disorders at the population level.

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