No abstract

Nitric oxide (NO) plays an important role in metabolism. Consequently, every tissue of our body is affected by changes in concentrations of nitric oxide and its metabolites. Here we analyze phenotypic effects of NO and its metabolites in macrophages, NK-cells and lymphocytes that perform protection of the host organism against malignant tumors and intracellular pathogens. Immune system imbalance may result from misregulation of NO synthesis. Nitric oxide also plays an important role in endothelial dysfunction including inhibition of platelet adhesion and aggregation, vasoconstriction and vasodilation disorders of blood vessels, blood rheology changes and the development of atherosclerotic plaques. Thus an imbalance in the synthesis of nitric oxide in the vascular endothelium may be an early marker of lesions of various origins. K e y w o r d s: NO

<p>Most everyone extreme condition of the body and the disease process directly or indirectly linked with<br />polyfunctional properties of nitric oxide. Therefore, further study of the effects of nitric oxide in medicine and research<br />in the process of obtaining new scientific facts about the peculiarities of the biosynthesis of this compound and the<br />ways to implement its molecular biochemical impact allow me to develop a new strategy and tactics of correction<br />and treatment of pathologies of various origins.</p>