Nitric oxide (NO) plays an important role in metabolism. Consequently, every tissue of our body is affected by changes in concentrations of nitric oxide and its metabolites. Here we analyze phenotypic effects of NO and its metabolites in macrophages, NK-cells and lymphocytes that perform protection of the host organism against malignant tumors and intracellular pathogens. Immune system imbalance may result from misregulation of NO synthesis. Nitric oxide also plays an important role in endothelial dysfunction including inhibition of platelet adhesion and aggregation, vasoconstriction and vasodilation disorders of blood vessels, blood rheology changes and the development of atherosclerotic plaques. Thus an imbalance in the synthesis of nitric oxide in the vascular endothelium may be an early marker of lesions of various origins. K e y w o r d s: NO

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Ii is established in experimental work that allergic alveolitis (AA) is accompanied by disorders in the functional state of prooxidant and antioxidant systems in lungs. The content of dienic conjugates and malonic dialdehyde increases and the activity of catalаse and ceruloplasmin decreases in lungs of Guinea pigs in the process of development of experimental allergic alveolitis, on 44th and 54th days, in particular. The use of thiatriazolin causes the correcting effect on the mentioned indices.

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We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd  day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.