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ВСТУП. Бурхливий розвиток цивілізації, особливо в останні десятиріччя, призвів до погіршення екологічної ситуації на нашій планеті. Дію різних шкідливих чинників, забруднення на-вколишнього середовища, а нерідко їх поєднаний вплив називають однією з найвагоміших причин зростання алергізації населення. Поширеність алергічних захворювань у різних країнах коли вається від 20 до 35 %, і, згідно з прогнозами Європейської комісії з питань алергології, до середини ХХІ століття ці захворювання можуть уразити більш ніж 50 % населення нашої планети [1,9,10]. Цей тривожний прогноз обґрунтований тим, що імунна система організму людини не завжди адекватно реагує на постійне зростання антигенного навантаження та на динамічну зміну складу антигенів [8,10]. Cеред алергічних захво-рювань бронхолегеневої системи важливе місце посідає бронхіальна астма (БА) [8]. Актуальність її проблеми визначається поширеністю, значною часткою інвалідизації, певним рівнем смертності дітей з цією патологією. Слід зазначити, що кіль кість видів даного захворювання щорічно зростає. Це пов'язано з використанням нових лікарських препаратів та науковотехнічним про-гресом, застосуванням різних хімічних засобів у побуті тощо [1,6]. На даний час встановлено, що схильність організму до різних запальних і алергічних уражень легень та особливостей їх клінічного перебігу пов'язана зі станом імунної системи, яка бере активну участь у механізмах захисту організму [9].

Aim. Study of antioxidant (antiradical) activity of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine derivatives. Methods. In vitro study of antiradical/scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals inhibition assay; IC 50 values determination. Results. The series of 29 modified derivatives of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine were evaluated for their ability to scavenge DPPH radicals in conditions close to physiological at 5 mM concentration, and the IC 50 values were determined for the most promising compounds using the serial dilutions method. The structure -antiradical activity correlations were performed and possible mechanisms of action were discussed. Conclusions. Tested 6,7-dihydro-5Himidazo[2,1-b][1,3]thiazine derivatives possess a moderate level of antiradical/scavenging activity. K e y w o r d s: 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine; antiradical/scavenging activity; DPPH; IC 50 ; SAR

The aim of this work was to find out the specifics of changes in endogenous intoxication, middle mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of animals for experimental asthma in different periods of its development and to correct them by thiotriazolin. Material and methods. Researches were carried out on 72 guinea-pigs (males), which were divided into 6 groups for 12 animals in each of them. The last sixth group included animals that were treated by thiotriazolin. The drug thiotriazolin rate of 100 mg / kg intramuscularly since 23rd day of the experiment for 10 days was administered in the animals of sixth group. Experimental model of bronchial asthma was restored on guinea-pigs by the V.I. Babych method (1979). In all groups of animals there were determined the middle mass molecules concentration in blood in the wave of 254 nm by I.A.Volchehorskiy, D.A.Dyatlova, E.I. Lvovska and others methods and EII by V.K. Kazymyrko V.I. Maltsev methods. Numerical results were adapted with static method using Student’s criteria. Results of the research. The highest level of endogenous intoxication in the blood was in the fifth group of guinea pigs with asthma (33rd day), indicating the direct dependence of the antigenic effect on their severity. Using of the thiotriazolin within 10 days (from 23rd to 33rd day) caused the decrease of the MMM254 concentration and EII in serum compared with a group of guinea pigs, that were not entered the medicine. It approved its treating effect. Conclusions. So, the research of middle mass molecules and erythrocyte intoxication index indicators in different periods of experimental asthma showed their gradual increase in serum of guinea pigs with the greatest severity in 33rd day of the experiment. It might indicate the development of endogenous intoxication animals. But the using of thiotriazolin caused the decreasing of these indicators. That gives a reason to state its positive effect on some markers of endogenous intoxication and feasibility of further researches.

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Introduction: as there is a growing number of percutaneous interventions, scrupulous attention and profound knowledge of the aortic root and neighboring structures is required. The objective of the study is to describe the anatomy of the aortic root and the coronary ostia in asymptomatic patients using CT. Methods: eighty-five patients without any clinical symptoms suggestive of the aortic root and coronary arteries diseases underwent contrast-enhanced MDCT. CT angiography was performed with a 64-row helical CT scanner after administration of the non-ionic, iodinated contrast agent. Results: CT angiography depicted the entire structure of the aortic root. The aortic root encompasses several distinct elements, namely the aortic annulus, the aortic valve leaflets and their (leaflet) attachments, the interleaflet triangles, the sinuses of Valsalva, the coronary arteries ostia and the sinotubular junction. CT angiography depicted the distance between the aortic annulus and the margins of the left and right coronary ostia. While carrying out the analysis, the precise description of the anatomy of the sinotubular junction and the valve leaflet attachments has to be made. Sinuses of Valsalva normally consist of the right, left and posterior cusps. Left and right coronary ostia are located below the upper margin of the cusps. Conclusion: When analyzing the anatomy of the aortic root and the coronary ostia, each entity should be examined separately. It is important to take into account the relationship between the structures the aortic root encompasses. Changes in the size of one structure cause the improper functioning of the adjacent ones.