The aim: Of the study is to analyze the literary data regarding evaluation of the pathogenetic mechanisms of the interaction of systemic diseases and periodontal tissue damage, conducted on the basis of scientific researches of Ukrainian and foreign scientists. Materials and methods: Bibliosematic and analytical methods were used in the research. The materials of the exploration are international experience in the study of pathogenetic mechanisms of the interplay of pathology in the cardiovascular, respiratory systems, diseases of the gastrointestinal tract and chronic generalized damage of periodontal tissues. Conclusions: It is important to search for new modern methods of diagnosis and individual approach to primary and secondary prevention of changes in periodontal tissues on the background of general pathology. The only way to solve this problem is a detailed study of somatic and dental history, changes in all body systems, on the basis of which it is possible to create a reasonable set of individual preventive measures and improve the treatment of periodontal disorders.

Introduction: Over the years, heart failure remains one of the most common and prognostically unfavorable conditions. The aim of our study was to determine the frequency of complications in patients with CHF depending on the body weight and intoxication syndrome of varying degrees of severity. Materials and methods: A complete clinical examination was performed in 58 patients (41 (70.6%) men and 17 (29.4%) women) with CHF. In addition to the standard examination in accordance with the protocol, the level of endogenous intoxication was determined by the level of medium-weight molecules (MWM254) and leptin. The patients were randomized into 4 groups depending on their body mass index and the degree of endogenous intoxication. Statistical processing of the results was carried out using the methods of variation statistics “Statistica 6.0”. Results: It was revealed that the worst survival rate is observed in patients with normal body mass against the background of the expressed endogenous intoxication syndrome, the best survival rate is observed provided that there are a normal body mass and endogenous intoxication of a minimum degree. An inverse correlation between the body mass index and the endogenous intoxication indicator (blood MWM) was detected. Patients with CHF should have their leptin level evaluated. An increase in its level was associated with arterial hypertension, an increase in blood glucose levels and lipid metabolism disorders. Conclusions: Increased level of blood MWM worsens the forecast of CHF. The unfavorable outcome was observed in patients with the combination of hypoleptinemia with severe endogenous intoxication.

The aim: To study the effect of drug addiction and smoking on the status of periodontal tissues in patients with hepatobiliary pathology. Materials and methods: 58 smokers, 63 drug addicts with hepatobiliary pathology were examined and 92 persons of comparison group (with inflammatory periodontal diseases affected by hepatobiliary pathology, without addiction). Examination of patients included determination of iodine number by Svrakov, S-L and Stallard hygiene indices, PMA index and index PBI. Results: The results of examination of smokers are worse in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov – 1,4 times and 1,3 times higher, PMA index – 1,7 times and 1,4 times worse, in accordance). The results of the study showed that drug addicts patients are worse values in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov – 1,5 times and 1,4 times higher, PMA index – 1,7 times and 1,5 times worse, in accordance). Conclusions: Presence of hepatobiliary pathology in smokers and drug addicts increases the risk of periodontal diseases.

Introduction: Small intestinal bacterial overgrowth may cause the hyperlipidemia appearance by enterohepatic circulation disturbance which evolves on the background of the early bile acids deconjugation with further endotoxin production and oxidative stress in the liver with hyperproduction of cholesterol and atherogenic lipoproteins. The aim: the determination of prevalence and features of SIBO in a series of patients with hyperlipidemia and in control subjects. Materials and methods: Nineteen patients with hyperlipidemia and ten control subjects were studied. Small intestinal bacterial overgrowth was assessed by a lactulose breath test. Such biochemical markers as CRP, ALT, AST, GGTP, apolipoprotein B, bilirubin, cholesterol and lipid profile were determined. Except the routine interpretation of lactulose breath test, which contains the SIBO detection, small intestinal transit time and hydrogen level evaluation with next comparison between groups of patients was realized. Results: Small intestinal bacterial overgrowth was present in 78.9% of patients with hyperlipidemia and 40% in control subjects. The maximal dose of H2 was particularly higher in patients with hyperlipidemia in comparison with control group (94,7±13,69 vs. 36,13±5,4). There was a strong correlation between AST level and SIBO existence in both groups (r=1). Positive connection between LDL, TG, VLDL and the dose of exhaled hydrogen on 120 minute (r=0.6, r= 0.62, r=0.7 respectively) and strong negative correlation between HDL and 120 minute dose (r=-0.74) in main group was marked. Conclusions: Patients with hyperlipidemia have a higher prevalence of small intestinal bacterial overgrowth and there is a relationship between H2 rate and LDL, TG, VLDL.

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A particular status of the English language as the language of international communication and connections between the nearly related English and German languages resulted in the emergence of many interlingual borrowings in the Modern English and German language vocabularies. The paper aims to consider the functioning of borrowings (loanwords) in the English and German languages. To reach the aim of the research and to carry out the tasks assigned, the following methods were used: a descriptive method, the method of correlation, componential analysis and, comparative semantic analysis. The paper focuses on linguistic and extralinguistic factors of the German and English interaction. Special attention is paid to clarifying the notion of borrowing in modern linguistic science. The word-formative calques and half-calques (hybrids), which differ from ordinary lexical borrowings by using partially borrowed lexical material, are identified in addition to direct lexical borrowings in the language subsystem under study. The paper demonstrates the significant influence of English borrowings on the structural-semantic qualities of German words, on various semantic changes, as well as on the participation of loanwords in the lexico-semantic variation: synonymy, polysemy, homonymy, and antonymy. The results of the research can also be used in the teaching and learning of both languages, in the course of lexicology or linguistics.

Оцінювання впливу стадії фіброзу печінки на клінічний перебіг захворювань пародонта у хворих із хронічним гепатитом С О. М. Слаба, Л. Ю. Мінько, Х. А. Січкоріз, І. О. КіселикЛьвівський національний медичний університет імені Данила Галицького, Україна Мета роботи -оцінити вплив стадії фіброзу печінки на клінічний перебіг захворювань пародонта у хворих із хронічним гепатитом С.Матеріали та методи. У стоматологічне дослідження включили 122 особи, які хворі на хронічний гепатит С в ана мнезі та лікувались у 7 відділенні Львівської обласної інфекційної клінічної лікарні протягом 2013-2015 років. Діагноз захворювань пародонта встановлювали відповідно до класифікації М. Ф. Данилевського (1994). Клінічний стан тка-нин пародонта оцінювали за допомогою папілярномаргінальноальвеолярного індексу (РМА) в модифікації Parma; пародонтального індексу (РІ); ступеня кровоточивості ясенних сосочків (РВІ). Стадію фіброзу встановлювали згідно з даними медичної карти хворого. Значущість різниці між двома та більше відносними показниками розрахована за допомогою тесту Фішера з Metropolis алгоритмом. Вивчення кореляційної залежності між клінічним станом тканин пародонта та стадією фіброзу печінки у хворих на хронічний вірусний гепатит С здійснили за допомогою рангового коефіцієнта кореляції Спірмена.Результати. Найбільший відсоток хворих зі стадією фіброзу печінки F 0 (70,00 ± 15,28 %) зареєстрований в осіб зі здоровим пародонтом, найменший -у хворих на генералізований пародонтит ІІІ ступеня важкості (7,89 ± 4,37 %). Найбільша частота хворих зі стадією фіброзу печінки F 3 (73,68 ± 7,14 %) також спостерігалась в осіб, які страждають на генералізований пародонтит ІІІ ступеня важкості (73,68 ± 7,14 %).Висновки. Важкість ураження тканин пародонта статистично значуще (р < 0,001) залежить від стадії фіброзу печінки у хворих на хронічний гепатит С. Між клінічним станом тканин пародонта та стадією фіброзу печінки у хворих на хронічний гепатит С встановлений прямий кореляційний зв'язок (R = 0,70; р < 0,001).Оценка влияния стадии фиброза печени на клиническое течение заболеваний пародонта у больных с хроническим гепатитом С О. М. Слаба, Л. Ю. Минько, К. А. Сичкориз, И. А. Киселик Цель работы -оценить влияние стадии фиброза печени на клиническое течение заболеваний пародонта у больных с хроническим гепатитом С. Материалы и методы.Обследовано 122 пациента с хроническим гепатитом С (г. Львов). Установление диагноза за-болеваний пародонта проводили в соответствии с классификацией М. Ф. Данилевского (1994). Клиническое состояние пародонта оценивали по папиллярномаргинальноальвеолярному индексу (РМА) в модификации Parma, пародонталь-ному индексу -РI (A. L. Russel, 1956), индексу Muhlemann и Son -степень кровотечения в области десневых сосочков (РВИ). Стадию фиброза устанавливали по данным медицинской карты. Значимость различия между двумя и больше относительными показателями рассчитана с помощью теста Фишера с Metropolis алгоритмом. Изучение корреляцион-ной зависимости между клиническим состоянием тканей пародонта и стадией фиброза печени у больных ви...

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