Periodontal Status in Patients With Diseases of Hepatobiliary System, Burdened With Tobacco and Drug Addiction

Фурдычко, А. И.; Ilchyshyn, M. P.; Fedun, I. R.; Barylyak, Adriana; Slaba, O.; Khoroz, Lesya

doi:10.36740/wlek202003121

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…[36] Further to that it was stated that the presence of hepatobiliary pathology in substance abusers and smokers enhances the risk of periodontal disease. [37] A meta-analysis revealed a noteworthy association between periodontitis and NAFLD. However, this relationship lost its significance when various metabolic parameters were taken into account.…”

Section: Periodontal Problems and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Hatipoglu

2024

J Inonu Liver Transpl Inst

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T he Non-alcoholic fatty liver disease (NAFLD) it's a term used for several conditions caused by fat accumulation in the liver. One-fourth of the world's population is faced with this clinical situation. It is mostly seen in South America and the Middle East, and least in Africa. [1] Nevertheless, when considering its prevalence within the community, this malady emerges as one of the most frequently encountered liver diseases, demonstrating a notable association with elevated rates of liver-related mortality and morbidity. [2] By definition, NAFLD is a clinical picture in which insulin resistance, histopathological more than 5% steatosis of hepatocytes, or dense fat fractions by radiographic techniques are detected. This clinical situation is examined under two main headings non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (steatosis coexists with liver-cell injury and inflammation). [3,4] NAFLD has 4 stages for developing; simple fatty liver (steatosis), non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and may liver cancer. [5] In advanced phases, this may result in liver transplantation. The patients with NAFLD show similar histological damage to alcoholic liver disease. [6] Oxidative and inflammatory responses play crucial roles in the shared pathogenesis of both NAFLD and nonalcoholic NASH. [7] Lifestyle is an important point for developing this disease.Periodontal disease is a common inflammatory disease and is known to be related to other systemic diseases. This bidirectional relation between periodontal disease and other disease processes has led to outstanding research recently. In addition, periodontal disease has been advocated to exacerbate metabolic disorders including non-alcoholic fatty liver disease (NAFLD). In this traditional review, general characteristics of periodontal diseases, general characteristics of NAFLD/ Nonalcoholic steatohepatitis (NASH), and their causality were discussed for treatment providers. The collected data significantly corroborate a greater incidence of periodontal disease among individuals with NAFLD in comparison to the general healthy population. Healthcare professionals need to be aware of the association between NAFLD and periodontal disease thus patient management effectiveness can be enhanced.

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Section: Periodontal Problems and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Hatipoglu

2024

J Inonu Liver Transpl Inst

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“…Оскільки захворювання тканин пародонта виникають внаслідок низки причин, передумовою їх розвитку можуть бути зміни в різних органах і системах організму людини. Численні дослідження доводять, що розвиток і перебіг хвороб пародонта патогенетично тісно пов'язаний із системними захворюваннями організму, які часто є визначальними факторами у розвитку цих стоматологічних хвороб [1][2][3][4].…”

Section: оцінка стану тканин пародонта у хворих із соматичною патологієюunclassified

“…За даними низки авторів захворювання пародонта зустрічаються у 90 % дорослого населення (старших 35 років), серед загальної структури стоматологічних захворювань їх поширеність досягає максимально 85 % [1,2,4,5]. На сьогодні проведено безліч досліджень, які свідчать про знач ний вплив захворювань органів та систем організму людини на розвиток патологічних процесів порожнини рота [3,6,7,9,11,12]. Однак, залишається відкрит им багато питань пов'язаних із захворюванням тканин пародонта у осіб із соматичною патологією.…”

Section: медичні наукиunclassified

Assessment of the Condition of Periodontal Tissues in Patients with Somatic Pathology

Фурдычко¹,

Fedun²,

Ilchyshyn³

et al. 2023

Ukr. ž. med. bìol. sportu

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The purpose of the study was to investigate the influence of concomitant somatic pathology on periodontal tissues. Materials and methods. 104 patients, aged 28–46 years, with diseases of periodontal tissues, who had somatic pathology, were involved in the study. The examined persons were divided into groups: 35 persons (group 1) with pathology of the hepatobiliary system, 37 persons (group 2) with pathology of the gastrointestinal tract, and 32 persons (group 3) with pathology of the cardiovascular system. The comparison group included 30 people with periodontal tissue diseases without somatic pathology. To determine the depth and prevalence of the inflammatory process of the gums the Svrakov’s number indicator was used. Oral hygiene was assessed according to the Silness-Loe and Stallard indices. The papillary-marginal-alveolar index (C. Parma, 1960) was determined to assess the severity of gum inflammation. Bleeding gums were assessed by the gum's papilla bleeding index according to Muhllemann. Statistical processing of the research results was carried out with a computer program for variational and statistical analysis of medical and biological research data “GraphPad Prism 5”. Results and discussion. Patients with diseases of periodontal tissues against the background of somatic pathology had the highest percentage of chronic generalized periodontitis of the II degree, in contrast patients of the comparison group had the highest percentage of chronic generalized periodontitis of the initial – I degree. Svrakov's number in patients with periodontal disease against the background of somatic pathology significantly (р ˂0.05) exceeded the indicators of patients of the comparison group. At the same time, there is no significant difference between the results of groups 1, 2 and 3. The highest values of the indexes of Silness-Loe and Stallard were recorded in patients with the cardiovascular system pathology, which significantly (p<0.05) exceeded the data in the comparison group, but did not significantly differ from the results of patients with pathology of hepatobiliary system and gastrointestinal tract. The papillary-marginal-alveolar index data were the highest in patients with hepatobiliary system pathology (64.25 ± 8.19%), which significantly (p<0.05) exceeded the results of the comparison group and in individuals of groups 2 and 3. The highest indicator of the bleeding index is 1.98 ± 0.22 points in patients of the 1st group, which significantly exceeds the indicators in the group of people without somatic pathology and in the group of patients with pathology of gastrointestinal tract and cardiovascular system. Conclusion. The conducted studies show that the presence of somatic pathology contributes to the development of periodontal tissue diseases, and certainly aggravates their course, which is proven by the results of the index assessment

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“…Слід відмітити, що зловживання наркотичних речовин провокує розвиток специфічних змін тканин і органів ротової порожнини із прогресуванням агресивних форм захворювань пародонту [10,11]. З метою підвищення ефективності лікування наркозалежних осіб, ряд авторів рекомендують застосовувати етіотропну та патогенетичну терапію [5,12,13].…”

Section: вступunclassified

Microstructural Organization of Periodontium Under Conditions of Complex Correction Against the Background of Experimental Ten-Week Opioid Exposure

Fik

Podolіyk²,

Matkivska³

et al. 2022

pulse

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In order to develop an adequate scheme of drug correction of periodontal tissue damage on the background of long-term action of the opioid analgesic nalbuphine, experimental studies were performed using the drugs pentoxifylline and ceftriaxone. The study was performed on male rats (24), which were divided into 3 groups. And the group is a control group. Group II – administration to rats of opioid analgesic in increasing doses for 10 weeks, where the initial dose was – 0.212 mg / kg, 9-10 weeks – 0.283 mg / kg. Group III – administration of pentoxifylline (7-10 weeks) and ceftriaxone (9-10 weeks) at a dosage of 2.86 mg against a 10-week opioid effect (from 0.212 to 0.283 mg / kg). For histological examinations, fragments of the dental segment of rats were collected using complex decalcification of the hard tissues of the dental organ. Microscopic studies in animals at 10 weeks of opioid action indicated pronounced inflammatory-dystrophic changes in periodontal tissues, which were manifested by necrotic changes in the mucous membrane of the gums, dystrophic periodontal damage and vascular disorders. Drug correction with pentoxifylline and ceftriaxone on the background of ten weeks of opioid action led to a protective effect on the microstructural organization of periodontal tissues of rats. Although complete restoration of periodontal structures in comparison with the control did not occur, however, the use of etiopathogenetic treatment contributed to a certain stabilization of the inflammatory process. The results showed that the use of pentoxifylline and ceftriaxone prevented the generalized progression of dystrophic changes in the periodontium with long-term opioid action, compared with the detected pathological changes in periodontal tissues in animals under ten weeks of opioid administration without corrective action.

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Periodontal Status in Patients With Diseases of Hepatobiliary System, Burdened With Tobacco and Drug Addiction

Cited by 5 publications

References 8 publications

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Assessment of the Condition of Periodontal Tissues in Patients with Somatic Pathology

Microstructural Organization of Periodontium Under Conditions of Complex Correction Against the Background of Experimental Ten-Week Opioid Exposure

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